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Respiratory disease - Coggle Diagram
Respiratory disease
Asthma
Symptoms
Respiratory symptoms
Airway obstruction
Chronic airway inflammation
Airway obstruction
Due to airway mucosal oedema
Hypersecretion of mucus
Type 2 inflammation
Cytokines
Mast cell degranulates
Airway hyperresponsiveness
IgE, Allergens
memory T cells
Memory T cells
Reversible airflow limitation
Can be fixed with bronchodilators
Therapies
Bronchodilators
ICS
Anti inflammatory
Beta agonists
Oral corticosteroids
Use limited by systemic side-effects
Severe asthma
Cytokine targeting mAbs
Types
Eosinophilic
Responds to ICS
IL 13 IL4 IL5
Neutrophilic
Does not respond to ICS
COPD
Symptoms
Brochiolitis
Airway inflammation
Increased presence of T cells
Increased B cells
Tissue scarring
Chronic Bronchitis
Overproduction of mucus
Emphysema
Airway tissue destruction
Loss of airway tubes
Elastin fibre destruction
Loss of alveolar walls
Drugs
Brochodilators
Steroids
Vaccines