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COVID 19 VIRUS EVOLUTION, Current Covid 19 Virus, Further Mutation,…
COVID 19 VIRUS EVOLUTION
Ancestor Covid 2019 Virus
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Sampling Locations+
Wuhan
Zhejiang
Nonthaburi
N protein
Virion Assembly
Virus Transcription
Assembly efficiency
Codon Usage Bias
Snake - Viral Source??
Virus Reservoir Human Infection
Cross species transmission
Homologous Recombination
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Spike Glycoprotein
Natural Selection
Compositional Properties
Gene Expression
Mutation Pressure
Dinucleotides
Bat SARS-like Virus (China 2015)
Genetically Homologous
Similar with Two Viral Proteins
Similar Nucelocapsids
Similar Proteins
BAT
Human
Positive Selective Pressure
Led by epidemic evolution
Favor transmission of COVID19 Virus
Favor enhancement of disease development
Key steps for Viral Infection & Disease Development
Protein binding to Cell Receptor
Membrane Fusion
Two Important Characteristics (compared to bat-like SARS)
Enhanced pathogenicity
Initial Lower severity than SARS
Higher ability to infect
Explain Zoonotic Transmission
Current
Covid 19 Virus
Further Mutation
Coronavirus Sequences
Clustered
Transmission Chain