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Management of Ovarian Cysts in Postmenopausal Women
(GTG 34 - Jul 2016),…
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A woman is a high risk of ovarian cancer if she has a 1st degree relative affected by cancer within a family with:
- Two or more individuals with ovarian cancer, who are 1st degee relatives of each other
- One individual with ovarian cancer at any age and one with breast cancer diagnosed under age 50 who are 1st degree relatives of each other
- One relative with ovarian cancer of any age and two with breast cancer diagnosed under age 60 who are connected by 1st degree relationships
- Three or more family members with colon cancer, or two with colon cancer and one with stomach, ovarian, endometrial, urinary tract, or small bowel cancer in two generations. One of these must be diagnosed under age 50 and affected relatives should be 1st degree relatives of each other
- One individual with both breast and ovarian cancer
A woman is also at increased risk of ovarian cancer if:
- Known carrier of relevant cancer gene mutations (BRCA1, BRCA2)
- Untested 1st degree relative of an individual with a relevant cancer gene mutation
- Untested 2nd degree relative, through an unaffected man, of an individal with a relevant cancer gene mutation
Risk Malignancy Index (RMI)
CA125 X Menopausal Status X Ultrasound Score
CA125: Measured in IU/ml
Menopausal status: Premenopause (1); postmenopause (3)
Ultrasound score: 1 point for each of multilocular cysts, solid areas, metastases, ascites, bilateral lesions
U = 0 (Ultrasound score 0)
U = 1 (Ultrasound score 1)
U = 2 (Ultrasound score 2-5)
B Rules
Unilocular cysts
Presence of solid components where largest <7mm
Presence of acoustic shadowing
Smooth multilocular tumour largest diameter <100mm
No blood flow on colour Doppler
M Rules
Irregular solid tumour
Presence of ascites
At least 4 papillary structures
Irregular multilocular solid tumour largest diameter =/>100mm
Prominant blood flow on colour Doppler