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Stem Cells - Coggle Diagram

- - - - Autonomy
      - Non-maleficence
      - Justice
      - Beneficence
- - - - Regenerative medicine (Cellular therapy, regulation of endogenous stem cells)
      - Bioengineering (Decellularisation)
      - Gene Therapy
      - Immunomodulation with MSCs
    - - Diversity of cells
      - Complex architecture
      - Manipulation of microenvironment
      - Range of disease pathophysiology
      - Scarcity of cell surface markers to isolate progenitor cells
- - - - 3D printing
    - - Layer-by-layer (LbL) Assemblies
      - Nano-scale clustering of integrin-binding ligands
      - Multiple Biomolecule delivery
        
        Biomolecule size affects release rate
    - - Neopec project: In vivo bioreactors
- - - - chemotherapy/radiotherapy
    - - immunosuppression
      - HLA matching
    - - methods
        
        umbilical cord blood
        
        amphresis of G-CSF mobilised SC
        
        BM harvest
      - autologous vs allogenic donor
    - - repair/reconstitute blood cell system
      - genetically modified to "correct" diseased haemopoietic system
      - potential immunotherapy with GvHD
    - - from chemo/radio-therapy
        
        haemorrhaig cystitis
      - GvHD
      - disease relapse (e.g. cancer)
      - secondary infection
      - .etc
- - - - tissue stem cells
      - pluripotent stem cells
  - - - con: lacks consistency, has morphological variation
    - - individual drug response
    - - possible transplantation
        
        cannot make full organ