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Humans, Brain Hormones, Aging, Carbohydrates, file-20180710-70063-w6mmdf -…

- - - - As cells age, genetic mistakes start to build up
    - - Cells can repair damage to their cells
      - But even repair mechanisms eventually get gummed up. Then the cell starts to get old.
    - - Any organism from yeast cells to cats. If caloric intake is reduced by 30% they live 30% longer.
        Only humans are not tested by scientists.
      - This is independent of Telomerase.
        It reduces the wear and tear of the cells.
        This is the only known way of extending lifespan.
      - Scientists want to find a genetic way of mimicking this mechanism without having to starve yourself.
      - Sirtuin
        
        There are Sirtuin Genes that control the process.
        They stimulate certain enzymes among them resveratrol that is found in red wine.
        
        Sur2 is one Sirtuin Gene for example.
        Scientists are finding pieces of the fountain of youth, but they don't have it yet to unravel aging.
  - - - At early times, people didn't have food all the time.
        They ate when they got food.
      - Promotes the growth of new neurons in your brain
      - Linked to prevent neurodegenerative diseases.
        Like Parikinson's and Alzheimer's
      - Intermittent Fasting
        
        Not eating for 16 hours of the day
      - Linked to curing Cold, Headache, Constipation to arthritis, valvular heart disease and cancer
      - The life expectancy was low, due to the infant mortality rate, which was bringing numbers down.
      - There were fossil evidence that older survivors were extraordinarily robust.
  - - - DNA encodes on its genes the HLA.
        Human Leukocyte Antigen
      - HLA Genes
        
        You have a particular combination of HLA genes.
        It is your genotype.
        
        If a girl has antibodies to your HLA gentoype.
        It will not work out no matter how smooth or good you are.
      - HLA Antibodies
        
        You also have particular constellation of HLA antibodies
      - Ones, DNA is assessing others DNA.
        Her DNA is assessing your DNA relative to theirs.
        Assesses your health, robustness and propagation success
    - - 2 insertions
        
        You're buff muscular, but not that strong
      - 2 deletions
        
        You're extraordinarily strong, but doesn't get big
- - - - Cell
        
        Via an Insulin receptor.
        Glucose enters the cells to produce energy
        
        This can only happen at a certain rate
        
        Energy
      - Liver
        
        70g of glucose can be stored
      - Muscles
        
        200g can be stored
      - Fat Cells
        
        When you've stored all glucose you can.
        It has to go to your body fat.
        Because the Fat Cells have less complex machinery as the other cells
        
        Hormone sensitive Lipase
        
        Ketone Bodies
        
        Ketone Bodies produce energy for your cells through similar pathways as glucose
        
        They are much more stable, efficient and don't cause complications like Glycation
        
        You can't get energy out of fat cells.
        Because the hormone sensitive Lipase.
        Is sensitive to Insulin
        
        You still need energy, so you take a snack to get your blood sugar up in short term to get energy
      - Too much glucose can bind to the proteins and much up the machinery of the cells in harmful inflammatory process called Glycation