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Calcium homeostasis - Coggle Diagram

- - - - inhibits adenylate cyclase
        
        decreases cAMP to prevent PTH secretion
      - hyperparathyroidism: excess
        
        may be due to tumour
        can cause hypercalcemia and lead to too much vitamin D
      - hypothyroidism: lacking response to vitamin D
        can cause hypocalcemia
  - - - decreases activity of osteoclasts (bone cells)
      - increases production of inactive vitamin D
  - - - D3 increases Ca absorption (intestine) and bone resorption
    - - binds to RXR to be a gene regulator
        
        promotes genes to increase Ca levels
- - - - high affinity may be due to ionic radius