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papillomavirus(family), polyomaviridae - Coggle Diagram
papillomavirus(family)
def
host-species specific
share fewer similarities
receptors on 樹突細胞
HSPG
SDC-3
proteins(8-10)
L1, L2
形成capsid
E1~E8
non-structural
viral helicase 解旋酶
E6
inhibit CBP/p300 and p53 tumor suppressor
blocks paxillin（碰到停止生長）
activate protein1
structure
55 nm
circler ds DNA
non-envelope
icosahedral
infect
上皮和黏液層
基底細胞感染
early gene
基底細胞分裂
顆粒、棘狀層延後成熟
late gene
encode capsid
顆粒、棘狀層分化
release
cell death
10000-100000 virions
polyomaviridae
smaller