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Cystic Fibrosis - Coggle Diagram

- - - - In most cases, CF affects the lungs and bronchial tubes the most. Typically, mucus dehydration in the airways initiates the disease.
        While CF has a major effect on the lungs, the thick mucus that is produced by this disease can also be found in the digestive system, sweat glands, and reproductive tract. This can lead to malnutrition and poor growth in most pediatric patients because the mucus in their digestive tract is so thick, that the enzymes located there become trapped and cannot absorb nutrients. Many pediatric patients will present with very slow growth even they may be eating an adequate amount of food.
      - Cystic Fibrosis is caused by a mutation in the Cystic Fibrosis Transmembrane Conductance Regulator gene (Cftr). The role of Cftr proteins is to control the ions that pass through the cell membrane. Typically, when a Cftr protein becomes irregularly folded, it does not allow the plasma membrane to properly bring Chloride to the cell; which therefore does not bring enough water into the cell. This results in cells that produce mucus that is too thick due to the abnormal amounts of sodium and chloride at the cell membrane.