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- - - - conventional medicine
  - - - conventional medicine
    - - personal autonomy
        
        control
        
        health care decisions
      - compatible
        
        patients
        
        worldview
        
        nature and meaning of health and illness
        
        beliefs
        
        values
      - the dissatisfaction
        
        conventional treatment
  - - - non proven treatments
        
        the condition
    - - kava kava
        
        anxiety
        
        liver damage
      - vitamine c
        
        scurvy
        
        reduce the effect
        
        chemotherapy
        
        radiation therapy
      - st. johns wort
        
        depression
        
        reduce the effect
        
        immunosuppressants
        
        antiretrovirals
        
        cancer medicate ions
- - - - Swollen airways
  - - - Pertactin
      - Fimbrae agglutinogens
      - Flamentous hemagglutinins
      - Lipooligosaccaride
    - - Pertussis toxin
      - Tracheal cytotoxin
      - Adenylate cyclase
- - - - DNA vaccines
      - Recombinant vector vaccines
        
        platform-based vaccines
    - - Tetanus toxoid
    - - Attenuated
        
        OPV
      - Inactivated
        
        Whole cell pertussis
    - - Hepatitis B
  - - - Hepatitis B
    - - BCG
    - - Measles
    - - Flu Mist
    - - OPV
  - - - severe allergic reaction
    - - Chills
      - Pain, swelling, or redness
      - Headache
      - Mild fever
      - Feeling tired
      - Muscle and joint aches
- - - - Toxins from reaching ther cells
    - - Phagocytosis
    - - Classical pathway
  - - - Delta heavy chain
    - - Mu heavy chain
    - - Epsilon heavy chain
    - - Gamma heavy chain
    - - Alpha heavy chain
  - - - Disulfide bonds
    - - Antigen recognition and binding
      - Match diiferent epitopes for different antigens
    - - Flexability for the antibody
    - - Ineraction with immune system components
      - Antibody class
- - - - To break the physiological obstacles
    - - Use EBM
      - Be realistic
      - Avoid complexity
  - - - Mom's WhatsApp
    - - Protests
  - - - Workshops
      - Awareness campaigns
      - Improve education
- - - - Prevotella
      - Fusobacterium
    - - Pseudomonas
      - Streptococcus
    - - Firmicutes
      - Actinobacteria
  - - - Dentric cell will sample antigen
        
        Activate T cells
        
        Escalate the immune response
      - Mast cells will release histamine
      - Goblet cells discharge a thin layer of mucus
- - - - Bone marrow
    - - Thymus
        
        Secondary lymphoid organs
      - Th1
      - Th2
        
        IL-4, IL-5, IL-6
        
        Activate B cells
        
        Activate eosinophils
      - Th17
      - Treg
- - - - Molecular technique used to detect DNA sequences of the Bordetella Pertussis
    - - Blood test for antibodies
    - - The gold standard test for pertussis diagnosis
        
        Done by taking samples from nasopharynx & grow them in an agar plate
  - - - Parmacokinetics
        
        Distribute well in body fluids except CSF
        
        Given orally or by IV injections
        
        Metabolized in liver
        
        Eliminated via bile
      - Adverse effects
        
        Cholestatic jaundice
        
        Reversible ototoxicity
        
        GI disturbance
      - Mechanism
        
        Inhibiting bacterial protein synthesis
        
        Binding to 50S ribosomal subunit & inhibiting translocation of newly synthesized peptidyl tRNA to P site
      - Contraindication
        
        Patients with hepatic dysfunction
        
        Patients with proarrhythmic conditions
      - Types
        
        Azithromycin
        
        Clarithromycin
        
        Erythromycin