SPINAL CORD INJURY download

Definition

Spinal cord injury (SCI) disrupts somatic and autonomic nervous system.


Many body systems are affected; the degree of
muscle paralysis, sensory loss, and autonomic impairment vary greatly.

SCI Causes

Respiratory

Musculoskeletal

Cardiovascular

Circulatory hypokinesis

Adaptive myocardial atrophy

Neurogenic Hypotension

Decreased Cardiac Output

Decreased Cardiac Reserve

Restrictive pulmonary disease

Obstructive pulmonary disease

Osteoporosis

Marked sacropenia

Metabolic

Obesity

Metabolic Syndrome despite normal body weight

Spinal cord serves as the major conduit for motor, sensory and autonomic neural information transmission between the brain and the body.
SCI affects conduction of neural signals across the site of the injury or lesion

Complete vs Incomplete / Paraplegia vs Tetraplegia

Paralegia: Impairment or loss motor and.or sensory function in the thoracic segments of the spinal cord. Includes trunk, legs and pelvic organs

Motor and sensory incomplete: Partial preservation of sensory or motor function below the neurological level, including the lowest sacral segment.

Motor and sensory complete: Without motor or sensory function in the lower sacral segment

Tetraplegia (Quadriplegia): Impairment or loss of motor and/or sensory function in the cervical segments of the spinal cord. Includes arms, trunk and legs

Causes & Impairments of SCI Clinical Syndromes

American Spinal Injury Association Impairment Scale

Non-traumatic SCI

Degeneration of the spinal column

Cancer

Arthritis

Circulation or bleeding problems

Infections

Inflammations

Spina Bifida / Myelomeningocele

Congenital SCI presents at birth with incomplete formation and closure of neural and skeletal bony elements.

Pathophysiology

The spinal cord, a portion of the CNS, links the conscious and subconscious functions of the brain with the peripheral and ANS


It extends through and is protected by the spinal column, a flexible segment of interdigitating bones and discs arranged to maximize mobility and reduce risk of injury.


7 Cervical, 12 Thoracic, 5 Lumbar, 5 Sacral & 4 Coccygeal

The spinal cord is about 25% shorter than the spinal column; thus spinal nerves below the first lumbar vertebral level exit from the cord as a bundle called the cauda equine.

Injury

Primary Injury

Secondary Injury

Damages the:

• Neural tract

• Cell bodies

• Vascular structures

• Due to haemorrhage and local oedema

• Compromise vascular supply

• Results in ischemia

• Inevitable, necrosis occurs and spread over the one or

two vertebral levels above and below the area of trauma

Systemic responses to exercise seen in nondisabled individuals are blunted
in persons with SCI.

Machanical Injury

Disruptions

Vasculature disruptions

Cell death

Shearing and compression forces

Alterations in ion and neurotransmitter levels

Membrane compromise

Inflammation

Neurogenic Shock

Respiratory difficulties

Excitotoxicity

Ischemia

Inflammation

Excessive Ca and ROS

Apoptosis

Activation of the ischemic cascade

Astrogliosis

Lymphocyte infiltration of lesion

Activated and phagocytic monocytes

Excessive CA leading to ROS production and oxidative stress

Excessive glutamate

Apoptosis

Nervous System

Somatic nervous system

Autonomic Nervous system

• Afferent (sensory) and efferent (motor) pathways transmission is interrupted.

• Voluntary movement and sensory perception are absent below the lesion.

Classification of SCI

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Effects of level of injury on Somatic and Autonomic Function

Systemic Adaptation

Clinical Considerations

Comorbidities affecting rehabilitation

Respiratory complications

Intra-abdominal trauma

Fractures

Plexopathies

Thoracic contusions

Peripheral neuropathis

Brain Injury

S&S

Signs

Symptoms

Flaccidity

Hypotension

Hperreflexia

Pulmonary dysfunction

Sensory loss

Neurogenic bladder

Motor paralysis

Neurogenic bowel

Flaccid paralysis with absent deep tendon reflexes

Dizziness or loss of consciousness

Brisk DTRs, spasticity, spasms, clonus

Accessory muscles of respiration required

Impaired or absent sensation

Urinary incontinence, urinary tract infection

Impaired or absent voluntary motor function

Fecal incontinence, constipation

History & Physical Examination

Comorbid medical issues

Circulatory hypokines (hypotensive)

Obesity

Peripheral arterial disease

Type 2 diabetes mellitus

Coronary artery disease

Pressure injuries

Respiratory complications

Joint contractures

Osteoporosis

High risk behaviours and SCI

Preinjury history of high- risk behaviours, including alcohol
abuse, is common.

Pharmacology

Heart disease & SCI

Second leading cause of death in patients (22% of all death


Silent myocardial ischemia caused by disrupted visceral afferent fibres in higher levels of SCI may prevent an individual from recognizing angina.

Amputations & SCI

• Greater risk of peripheral arterial disease.

• Complications related to reduced circulation.

• Sometimes results into amputations.

Pressure Ulcers & SCI

• Result of shear, friction, and unrelieved pressure over bony prominence.

• SCI unable to feel sentsation of tingling, discomfort and pain

• Wheelchair seating systems essential

Phantom Pain/Neuropathic Pain & SCI

Burning, tingling and picking sensations

May occur from a region below the SCI and can adversely affect exercise ability

Obesity & SCI

Diabetes type 2

Insulin resistant

Glucose intolerance

Skeletal muscle wasting below injury

↓ed RMR (12%)

↑ed fat mass

Joint Pain

• Wheelchair use – shoulder and wrist pain

• Hip, knee, and plantar flexion contractures due to unbalanced muscle forces in wheelchair-reliant individuals

Heterotopic Ossification & SCI

Formation of lamellar bone-like structures inside soft tissue where bones do not normally exist

Limit range of motion
Lose ability to transfer A
ffects certain ADL

Treatment
Biphosphonates
Radiotherapy
Surgical resection

Prevention.
Nonsteriodal anti-inflammatory agents & warfarin
Pulse low-intensity electromagnetic field therapy

Spasticity & SCI

Causes significant functional impairments

Inhibition of functional ambulation

Affect exercise ability

Pain & Fatigue

53-78% of SCI patient

Treatment

Increased risk of developing contractures and pressure ulcers

Difficulties with self-hygiene

Removal of any stimuli- inducing increased tone

Daily prolonged stretching of affected muscle group

Pharmacological management

Surgical management

Physical therapy

Coronary arterial disease risk

Women >= 50

Men >= 40

Diagnostic Testing

Additional Testing

Radiographs for asymptomatic fractures

Lipid profiles

DEXA for bone and mineral density

High-sensitivty C-reactive protein

Strength and flexibility measures

HbA1c for glucose intolerance and diabetes

Pulmonary function

Somatosensory evoked potentials

Non-invasive diagnostic test to assess the speed of electrical conduction across the spinal cord.


The technique involves applying electrical stimulus at specific nerves in the arms and legs and measuring the impulses generated by the stimulus at various points in the body.

Types of causes of vertebral fractures and dislocations

Myotomes & dermatomes

Exercise Testing

Tests

Establish a relationship between fitness and posttraumatic return to gainful employment and to determine how the fitness level of a person with SCI changes over time.

Arm crank ergometer is the most often used test mode with SCI.


Wheelchair ergometry is mobility specific for most SCI patients.

Wheelchair applied to torso improve trunk stability


Wheelchair gloves or flexion mitts with Velcro straps can prevent blisters, lacerations, and abrasions, especially for those with tetraplegia whose hands and fingers are insensate or unable to grasp sufficiently


Abdominal binders and leg wraps may improve pulmonary dynamics and venous return, which reduce the risk of hypotension.

Functional electrical stimulation

Externally applied electrical stimulation of neuromuscular elements to activate paralyzed muscles in a precise sequence and at a precise intensity to restore
muscular function.

Due to sympathetic impairment, peak heart rate rarely exceeds 120 beats/min in those with complete tetraplegia and T1-T3 paraplegia.


Variable responses occur in T4-T6


Most persons with SCI below T7 are able to reach their age-adjusted peak heart rate.


VO2peak and peak power output are significantly diminished in patients with SCI.
The lower the injury, the less the impairment

Persons with resting systolic BP lower than 100 mmHg should be closely monitored during exercise for the hypotensive response.


Tilt person back in wheelchair to promote venous return if symptomatic hypotension occur.

Musculoskeletal

Normally innervated muscles in persons with SCI is tested very similar to that in persons without SCI


Provided that the trunk is stabilized, balanced is ensured, and excessive axial loading of the spine or weight-
bearing skin is avoided.


Anaerobic Wingate arm ergometry can be used in testing with younger fit individuals and
athletes.

Flexibility

Joints should be moved passively, or actively, but always slowly, gently, and painlessly, especially if spasticity, tightness, or contracture is present.

❌ Contraindications ❌

❌ Absolute contraindications

❌ Relative contraindication

Peripheral neuropoathy

ecent deep vein thrombosis

Pulmonary embolism

Othostatic hypotension (with syncope)

Pressure ulcers (↑ risk of autonomic dysreflexia during exercise)


Autonomic dysreflexia resulting from recent fracture (precipitate spasms or ↑ed risk of fatty emboli, hypertensive crisis, or cerebrovascular events)

Pressure ulcers of grade 2 or less

Chronic heterotopic ossification

Spasticity

Active tendinitis (rotator cuff, eblow flexors, wrist flexors and extensors)

Bladder and bowel evacuation: Should be implemented immediately before the graded exercise test to minimize the risk of exertional incontinence or autonomic dysreflexia.


Thermoregulation: Environmental considerations are also necessary because of difficulty regulating body temperature

Exercise Prescription

Prescription

Special Considerations

Abdominal binders and leg wraps facilitate improved pulmonary dynamics and greater venous return

Functional electrical stimulation – leg cycling exercise (expensive to purchase an maintain)

Upper armband (Coban type) to prevent abrasions with wheelchair propulsion

Velcro straps and cuffed weights used for resistance exercise to improve or create grip

Adapted or adaptable equipment NB!

Lesions ↑ C4: limited to functional electrical stimulation (arm, trunk, leg paralysis)

Wheelchair access is essential

Lesions ↑ C4: Manual resistive exercise for inspiration

Barriers: transportation availability, assistance & finances (↓ed compliance)

Lesions ↑ C4: Passive range of motion exercises

Appropriate seating NB! To ↓ pressure ulcers, autonomic dysreflexia, spasticity and musculoskeletal trauma

Hybrid exercises – Functional electrical stimulation – leg cycling Promising exercise mode for cardiorespiratory training

Exercise in mildly temperate climate due to ↓ed thermoregulatory ability

Initial stages of program: focus on developing habit of exercise as adherence is low:
Succinct precise, and quantifiable goals optimize chances
Develop positive connection to exercise

Exercise Training Review

Type

Resistance exercise

Flexibility

Cardiovascular exercise

Increase VO2peak

Increase active muscles

Increase peripheral O2 extraction

Increase Venous Return

Circulatory Hypokinesis

High heart rate

Limited increase in cardiac contractility, stroke volume and arterial blood pressure

Characterised by lower increase in cardiac output per unit increase in VO2

Decrease in peripheral vascular resistance

Therapeutic recreaction

Effective physical activity program for people with SCI

Heart Rate Responses

• Controversial in people with tetraplegia and high-level paraplegia

• ↓ Heart rate

• ↓ Active muscle mass

• ↓ Sympathetic response

• Rather use RPE (11 – 14)

Caloric expenditure: Decreases CVD risk and weight management
Upper extremity overuse syndrome: Rather perform exercise session in bouts to avoid. Strain from too high volume of exercise

Muscles to exercise

Rotator cuff

Latissiums Dorsi

Scapular Stabilizers

Pectoralis Major

Trapezius

Rhomboids

Infraspinatus

Subscapularis

Supraspinatus

Teres minor

Balance of weights

Paralyzed lower extremities and truncal musculature significantly reduce a person’s ability to balance even small objects when lying supine or when seated without significant truncal support..

Free weights, isotonic or isokinetic machines

Wheelchair brakes should be set before lifting and care should be taken not to exceed the weight and stress limitations of the
wheelchair.

Maintain shoulder range of motion, especially external rotation and retraction and upward rotation of the scapula.

Active and passive stretching

• Incorporate both active and passive stretching.

• Be carful during passive stretching in joints lacking sensation (individual cannot determine when maximal range of joint has been reached).

Standing Frame - Should be medically cleared for full weight bearing

Exercise Training

Activities of Daily Living and SCI

Patients with longstanding (> 20 yr) SCI require greater physical assistance as they age.

Paraplegia vs Tetraplegia

% of maximal heart rate during performance of Activities of Daily Living and community mobility tasks is higher in people with tetraplegia than in those
paraplegia

Benefits of Upper extremity aerobic training


↑ed VO2peak


↑ed peak work rate

Improved body composition

↑ed functional capacity

↑ed stroke volume

Improved insulin resistance

Locomotor Training

Modalities

Benefits

Partial Body-weight-supported treadmill

Robotic assisted

Overground

Task-specific motor learning occurs and gait control and mechanics improve.


Chronic incomplete SCI: Approximately 80% of wheelchair-reliant individuals became independent walkers after locomotor training.

Resistance Exercise

Due to the large number of shoulder and upper extremity musculoskeletal problems encountered by persons with SCI, a prophylactic, structured, and progressively resistive strengthening program that focuses on scapular, rotator cuff, and pectoral muscles is likely to increase strength and reduce the risk of overuse injury.

Benefits of Resistance Exercise

↑ed Endurance


↑ed Anaerobic power

↓ed Shoulder pain

↑ed Dynamic strength

↑ed Activities of Daily Living

Improved body composition (↓ed fat mass

Functional Electrical Stimulation

↑ skeletal muscle endurance

↑ total body peak power

↑ HDL

Improved body composition

↑ Lower extremity bone mineral density

↑ stroke volume

↑ Myocardial disuse atrophy

↑ skeletal muscle strength

↑ Myocardial disuse atrophy

↑ Self-perception