SPINAL CORD INJURY
Definition
Spinal cord injury (SCI) disrupts somatic and autonomic nervous system.
Many body systems are affected; the degree of
muscle paralysis, sensory loss, and autonomic impairment vary greatly.
SCI Causes
Respiratory
Musculoskeletal
Cardiovascular
Circulatory hypokinesis
Adaptive myocardial atrophy
Neurogenic Hypotension
Decreased Cardiac Output
Decreased Cardiac Reserve
Restrictive pulmonary disease
Obstructive pulmonary disease
Osteoporosis
Marked sacropenia
Metabolic
Obesity
Metabolic Syndrome despite normal body weight
Spinal cord serves as the major conduit for motor, sensory and autonomic neural information transmission between the brain and the body.
SCI affects conduction of neural signals across the site of the injury or lesion
Complete vs Incomplete / Paraplegia vs Tetraplegia
Paralegia: Impairment or loss motor and.or sensory function in the thoracic segments of the spinal cord. Includes trunk, legs and pelvic organs
Motor and sensory incomplete: Partial preservation of sensory or motor function below the neurological level, including the lowest sacral segment.
Motor and sensory complete: Without motor or sensory function in the lower sacral segment
Tetraplegia (Quadriplegia): Impairment or loss of motor and/or sensory function in the cervical segments of the spinal cord. Includes arms, trunk and legs
Causes & Impairments of SCI Clinical Syndromes
American Spinal Injury Association Impairment Scale
Non-traumatic SCI
Degeneration of the spinal column
Cancer
Arthritis
Circulation or bleeding problems
Infections
Inflammations
Spina Bifida / Myelomeningocele
Congenital SCI presents at birth with incomplete formation and closure of neural and skeletal bony elements.
Pathophysiology
The spinal cord, a portion of the CNS, links the conscious and subconscious functions of the brain with the peripheral and ANS
It extends through and is protected by the spinal column, a flexible segment of interdigitating bones and discs arranged to maximize mobility and reduce risk of injury.
7 Cervical, 12 Thoracic, 5 Lumbar, 5 Sacral & 4 Coccygeal
The spinal cord is about 25% shorter than the spinal column; thus spinal nerves below the first lumbar vertebral level exit from the cord as a bundle called the cauda equine.
Injury
Primary Injury
Secondary Injury
Damages the:
• Neural tract
• Cell bodies
• Vascular structures
• Due to haemorrhage and local oedema
• Compromise vascular supply
• Results in ischemia
• Inevitable, necrosis occurs and spread over the one or
two vertebral levels above and below the area of trauma
Systemic responses to exercise seen in nondisabled individuals are blunted
in persons with SCI.
Machanical Injury
Disruptions
Vasculature disruptions
Cell death
Shearing and compression forces
Alterations in ion and neurotransmitter levels
Membrane compromise
Inflammation
Neurogenic Shock
Respiratory difficulties
Excitotoxicity
Ischemia
Inflammation
Excessive Ca and ROS
Apoptosis
Activation of the ischemic cascade
Astrogliosis
Lymphocyte infiltration of lesion
Activated and phagocytic monocytes
Excessive CA leading to ROS production and oxidative stress
Excessive glutamate
Apoptosis
Nervous System
Somatic nervous system
Autonomic Nervous system
• Afferent (sensory) and efferent (motor) pathways transmission is interrupted.
• Voluntary movement and sensory perception are absent below the lesion.
Classification of SCI
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Effects of level of injury on Somatic and Autonomic Function
Systemic Adaptation
Clinical Considerations
Comorbidities affecting rehabilitation
Respiratory complications
Intra-abdominal trauma
Fractures
Plexopathies
Thoracic contusions
Peripheral neuropathis
Brain Injury
S&S
Signs
Symptoms
Flaccidity
Hypotension
Hperreflexia
Pulmonary dysfunction
Sensory loss
Neurogenic bladder
Motor paralysis
Neurogenic bowel
Flaccid paralysis with absent deep tendon reflexes
Dizziness or loss of consciousness
Brisk DTRs, spasticity, spasms, clonus
Accessory muscles of respiration required
Impaired or absent sensation
Urinary incontinence, urinary tract infection
Impaired or absent voluntary motor function
Fecal incontinence, constipation
History & Physical Examination
Comorbid medical issues
Circulatory hypokines (hypotensive)
Obesity
Peripheral arterial disease
Type 2 diabetes mellitus
Coronary artery disease
Pressure injuries
Respiratory complications
Joint contractures
Osteoporosis
High risk behaviours and SCI
Preinjury history of high- risk behaviours, including alcohol
abuse, is common.
Pharmacology
Heart disease & SCI
Second leading cause of death in patients (22% of all death
Silent myocardial ischemia caused by disrupted visceral afferent fibres in higher levels of SCI may prevent an individual from recognizing angina.
Amputations & SCI
• Greater risk of peripheral arterial disease.
• Complications related to reduced circulation.
• Sometimes results into amputations.
Pressure Ulcers & SCI
• Result of shear, friction, and unrelieved pressure over bony prominence.
• SCI unable to feel sentsation of tingling, discomfort and pain
• Wheelchair seating systems essential
Phantom Pain/Neuropathic Pain & SCI
Burning, tingling and picking sensations
May occur from a region below the SCI and can adversely affect exercise ability
Obesity & SCI
Diabetes type 2
Insulin resistant
Glucose intolerance
Skeletal muscle wasting below injury
↓ed RMR (12%)
↑ed fat mass
Joint Pain
• Wheelchair use – shoulder and wrist pain
• Hip, knee, and plantar flexion contractures due to unbalanced muscle forces in wheelchair-reliant individuals
Heterotopic Ossification & SCI
Formation of lamellar bone-like structures inside soft tissue where bones do not normally exist
Limit range of motion
Lose ability to transfer A
ffects certain ADL
Treatment
Biphosphonates
Radiotherapy
Surgical resection
Prevention.
Nonsteriodal anti-inflammatory agents & warfarin
Pulse low-intensity electromagnetic field therapy
Spasticity & SCI
Causes significant functional impairments
Inhibition of functional ambulation
Affect exercise ability
Pain & Fatigue
53-78% of SCI patient
Treatment
Increased risk of developing contractures and pressure ulcers
Difficulties with self-hygiene
Removal of any stimuli- inducing increased tone
Daily prolonged stretching of affected muscle group
Pharmacological management
Surgical management
Physical therapy
Coronary arterial disease risk
Women >= 50
Men >= 40
Diagnostic Testing
Additional Testing
Radiographs for asymptomatic fractures
Lipid profiles
DEXA for bone and mineral density
High-sensitivty C-reactive protein
Strength and flexibility measures
HbA1c for glucose intolerance and diabetes
Pulmonary function
Somatosensory evoked potentials
Non-invasive diagnostic test to assess the speed of electrical conduction across the spinal cord.
The technique involves applying electrical stimulus at specific nerves in the arms and legs and measuring the impulses generated by the stimulus at various points in the body.
Types of causes of vertebral fractures and dislocations
Myotomes & dermatomes
Exercise Testing
Tests
Establish a relationship between fitness and posttraumatic return to gainful employment and to determine how the fitness level of a person with SCI changes over time.
Arm crank ergometer is the most often used test mode with SCI.
Wheelchair ergometry is mobility specific for most SCI patients.
Wheelchair applied to torso improve trunk stability
Wheelchair gloves or flexion mitts with Velcro straps can prevent blisters, lacerations, and abrasions, especially for those with tetraplegia whose hands and fingers are insensate or unable to grasp sufficiently
Abdominal binders and leg wraps may improve pulmonary dynamics and venous return, which reduce the risk of hypotension.
Functional electrical stimulation
Externally applied electrical stimulation of neuromuscular elements to activate paralyzed muscles in a precise sequence and at a precise intensity to restore
muscular function.
Due to sympathetic impairment, peak heart rate rarely exceeds 120 beats/min in those with complete tetraplegia and T1-T3 paraplegia.
Variable responses occur in T4-T6
Most persons with SCI below T7 are able to reach their age-adjusted peak heart rate.
VO2peak and peak power output are significantly diminished in patients with SCI.
The lower the injury, the less the impairment
Persons with resting systolic BP lower than 100 mmHg should be closely monitored during exercise for the hypotensive response.
Tilt person back in wheelchair to promote venous return if symptomatic hypotension occur.
Musculoskeletal
Normally innervated muscles in persons with SCI is tested very similar to that in persons without SCI
Provided that the trunk is stabilized, balanced is ensured, and excessive axial loading of the spine or weight-
bearing skin is avoided.
Anaerobic Wingate arm ergometry can be used in testing with younger fit individuals and
athletes.
Flexibility
Joints should be moved passively, or actively, but always slowly, gently, and painlessly, especially if spasticity, tightness, or contracture is present.
❌ Contraindications ❌
❌ Absolute contraindications
❌ Relative contraindication
Peripheral neuropoathy
ecent deep vein thrombosis
Pulmonary embolism
Othostatic hypotension (with syncope)
Pressure ulcers (↑ risk of autonomic dysreflexia during exercise)
Autonomic dysreflexia resulting from recent fracture (precipitate spasms or ↑ed risk of fatty emboli, hypertensive crisis, or cerebrovascular events)
Pressure ulcers of grade 2 or less
Chronic heterotopic ossification
Spasticity
Active tendinitis (rotator cuff, eblow flexors, wrist flexors and extensors)
Bladder and bowel evacuation: Should be implemented immediately before the graded exercise test to minimize the risk of exertional incontinence or autonomic dysreflexia.
Thermoregulation: Environmental considerations are also necessary because of difficulty regulating body temperature
Exercise Prescription
Prescription
Special Considerations
Abdominal binders and leg wraps facilitate improved pulmonary dynamics and greater venous return
Functional electrical stimulation – leg cycling exercise (expensive to purchase an maintain)
Upper armband (Coban type) to prevent abrasions with wheelchair propulsion
Velcro straps and cuffed weights used for resistance exercise to improve or create grip
Adapted or adaptable equipment NB!
Lesions ↑ C4: limited to functional electrical stimulation (arm, trunk, leg paralysis)
Wheelchair access is essential
Lesions ↑ C4: Manual resistive exercise for inspiration
Barriers: transportation availability, assistance & finances (↓ed compliance)
Lesions ↑ C4: Passive range of motion exercises
Appropriate seating NB! To ↓ pressure ulcers, autonomic dysreflexia, spasticity and musculoskeletal trauma
Hybrid exercises – Functional electrical stimulation – leg cycling Promising exercise mode for cardiorespiratory training
Exercise in mildly temperate climate due to ↓ed thermoregulatory ability
Initial stages of program: focus on developing habit of exercise as adherence is low:
Succinct precise, and quantifiable goals optimize chances
Develop positive connection to exercise
Exercise Training Review
Type
Resistance exercise
Flexibility
Cardiovascular exercise
Increase VO2peak
Increase active muscles
Increase peripheral O2 extraction
Increase Venous Return
Circulatory Hypokinesis
High heart rate
Limited increase in cardiac contractility, stroke volume and arterial blood pressure
Characterised by lower increase in cardiac output per unit increase in VO2
Decrease in peripheral vascular resistance
Therapeutic recreaction
Effective physical activity program for people with SCI
Heart Rate Responses
• Controversial in people with tetraplegia and high-level paraplegia
• ↓ Heart rate
• ↓ Active muscle mass
• ↓ Sympathetic response
• Rather use RPE (11 – 14)
Caloric expenditure: Decreases CVD risk and weight management
Upper extremity overuse syndrome: Rather perform exercise session in bouts to avoid. Strain from too high volume of exercise
Muscles to exercise
Rotator cuff
Latissiums Dorsi
Scapular Stabilizers
Pectoralis Major
Trapezius
Rhomboids
Infraspinatus
Subscapularis
Supraspinatus
Teres minor
Balance of weights
Paralyzed lower extremities and truncal musculature significantly reduce a person’s ability to balance even small objects when lying supine or when seated without significant truncal support..
Free weights, isotonic or isokinetic machines
Wheelchair brakes should be set before lifting and care should be taken not to exceed the weight and stress limitations of the
wheelchair.
Maintain shoulder range of motion, especially external rotation and retraction and upward rotation of the scapula.
Active and passive stretching
• Incorporate both active and passive stretching.
• Be carful during passive stretching in joints lacking sensation (individual cannot determine when maximal range of joint has been reached).
Standing Frame - Should be medically cleared for full weight bearing
Exercise Training
Activities of Daily Living and SCI
Patients with longstanding (> 20 yr) SCI require greater physical assistance as they age.
Paraplegia vs Tetraplegia
% of maximal heart rate during performance of Activities of Daily Living and community mobility tasks is higher in people with tetraplegia than in those
paraplegia
Benefits of Upper extremity aerobic training
↑ed VO2peak
↑ed peak work rate
Improved body composition
↑ed functional capacity
↑ed stroke volume
Improved insulin resistance
Locomotor Training
Modalities
Benefits
Partial Body-weight-supported treadmill
Robotic assisted
Overground
Task-specific motor learning occurs and gait control and mechanics improve.
Chronic incomplete SCI: Approximately 80% of wheelchair-reliant individuals became independent walkers after locomotor training.
Resistance Exercise
Due to the large number of shoulder and upper extremity musculoskeletal problems encountered by persons with SCI, a prophylactic, structured, and progressively resistive strengthening program that focuses on scapular, rotator cuff, and pectoral muscles is likely to increase strength and reduce the risk of overuse injury.
Benefits of Resistance Exercise
↑ed Endurance
↑ed Anaerobic power
↓ed Shoulder pain
↑ed Dynamic strength
↑ed Activities of Daily Living
Improved body composition (↓ed fat mass
Functional Electrical Stimulation
↑ skeletal muscle endurance
↑ total body peak power
↑ HDL
Improved body composition
↑ Lower extremity bone mineral density
↑ stroke volume
↑ Myocardial disuse atrophy
↑ skeletal muscle strength
↑ Myocardial disuse atrophy
↑ Self-perception