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CHRONIC LEUKAEMIAS, Other Lymphocytic Leukaemias, (Difficult) - Coggle…
CHRONIC LEUKAEMIAS
Chronic Lymphocytic Leukaemia/ Small Lymphocytic Lymphoma
Other Lymphocytic Leukaemias
Prolymphocytic Leukaemia
Treatment
Splenectomy
Purine nucleoside analogues
Rituximab
B-cell PLL 3x more common than T-cell PLL
Prolymphocytes
2x of small lymphocytes
large central nucleolus
Symptoms
Splenomegaly w/o lymphadenopathy
increased lymphocyte count
Anemia - poor prognostic feature :warning:
Appearance: majority of prolymphocytes (blood)
Hairy cell Leukaemia
Symptoms
Splenomegaly
Pancytopaenia
Anaemia
Monocytopaenia
Infections
Blood film: Large lymphocytes with villous cytoplasmic projections
Peak incidence: 40-60 years
Immunophenotyping: CD22+, FMC7+ and CD103+
Male:Female - 4:1
BM Trephine: mild fibrosis & diffuse cellular infiltrate
Uncommon
Treatment
Alpha-interferon
(Difficult)