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Proteins, Carriers, Active, transport, Channels - Coggle Diagram

- - - - Towards plasma membrane
    - - Towards nucleus
  - - - Attaches to cytoskeletal filament and has an ATP binding site (ATP hydrolysis)
    - - connects head and tail
    - - connects to cargo
  - - - Cytoskeleton can not move but motor protein can
    - - Motor protein can not move but cytoskeleton can
- - - - Integrin
        
        Attaches to fibronectin which attaches to collagen in the ECM
        
        Makes temporary attachments with blood cells
        
        Epithelial Integrin attaches to Laminin instead of Fibronectin which attaches to basal lamina
        
        Detaches from cytoskeleton and ECM when cell undergoes division by change in confirmation
        
        Ability to make temporary attachmetns
    - - cadherin
        
        Make up anchoring junctions
        
        Calcium mediated adhering protein
      - Tight junctions
        
        Occludin
        
        Claudin
  - - - Transmembrane proteins
        
        Present along length of membrane held in place by hydrophobic exclusion
        
        Very small percentage of genes involved in coding
      - Lipid anchored proteins
        
        Covalent association using tiny lipid molecule
      - Needs detergent to be completely isolated
    - - Periphereal proteins
        
        Held to lipids/transmembrane proteins by forces of attraction
      - Simply pour solution of opposite charge onto in order to isolate
- - - - creates 13 proto filaments
        
        Tube like due to polymerization of alpha and beta
    - - Negative end near nucleus
      - Positive end near plasma membrane
    - - Transport of cargo
      - Cytoskeleton
      - Form Spindella in division
    - - Microtubule organizing center
    - - 9 +2 arrangement of microtubules
        
        9 microtubules doublets radial spokes
        
        2 microtubules in center
        
        Nexin restricts
        
        Axoneme (?)
        
        Causes bending movement
      - Originates from basal body
        
        Below PM
  - - - No motor proteins
    - - Named for diameter
    - - Nuclear lamina supports nuclear membrane
      - Keratin
  - - - Can go towards PM or nucleus
        
        Polymerization towards PM allows organisms to move
        
        Does not make holes but stretches PM to make false feet (amoeba)
      - Attached to adhesive proteins
- - - - Most abundant protein in the body
      - Protein of great tensile strength
      - Procollagen
        
        Made of three alpha fibers
        
        Extension sequences (strings of amino acids) prevent pro extension of pro collagen
        
        Released out of cell
        
        Extension sequences eliminated
        
        Collagen fibrils
        
        Collagen fiber
    - - Present outside blood cells
        
        Can expand and contract due to present of covalent cross link
  - - - Connects Cells to ECM and helps organize components of the ECM
    - - Connects cells to ECM and helps to organize components of the Basal lamina, a specialized ECM found in Epitheleal cells
- - - - Confirmations
        
        E1
        
        Protein facing inward with capacity to bind to three sodium ions
        
        E2
        
        Protein facing outward with capacity to bind to two potassium ions
        
        Capacity to bind to potassium is due to release of sodium not connection of phosphate
        
        ATP is hydrolyzed in cell to form ADP and inorganic phosphate
        
        Phosphate binds to protein
        
        Phosphate is not attached to protein
      - Results in one extra positive charge on outside of cell
        
        Electrogenic
      - Ion electrochemical gradient
- - - - (Pressure/ sound waves)