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Microbial agents of eye dz :eye: - Coggle Diagram

- - - - Recombinant Pili vaccines
      - Bacterins - Killed whole cells
        
        "Cooper Piliguard"
        
        Effective against 77% of strains
        
        Pili antigen serotypes
        
        Non-recombinant haemolysin vaccines
        
        Vaccine failure possible
        
        Ideal: mucosal vaccine
    - - Shade - reduce UV exposure
      - Fly control
        
        Carrier + ocular irritant
      - :arrow_down: Stocking rates
        
        Isolate affected animals
    - - Cloxacillin
      - Long-acting tertracyclines
  - - - Eye condition
        
        Trauma - Foreign bodies :four_leaf_clover:
        
        Lacking eyelid pigmentation
        
        Protrusion
      - Concurrent infection
        
        Viruses
        
        Mycoplasma spp.
      - Lower immune response
        
        Poor body condition
        
        Younger stock <2 years old
        
        Lacrimation Ab
        
        Temporary protection
        
        Poor nutrition
        
        VtiA; Se,Cu deficiency
    - - Moraxella bovis / bovoculi
        
        Initiates infection
        
        Interaction with other pathogens eg. mycoplasma
        
        Virulence factors
        
        Fimbriae (pili)
        
        Attachment + persistence
        
        Haemolysin
        
        Cytotoxic
        
        Corneal epithelial cells
        
        Chemotactic neutrophils (inflammation)
        
        Gram -ve short rods
        
        Non-motile
        
        Obligates of mucous membranes
        
        Conjunctiva; URT
    - - Seasonal - summer :sunny: + Autum :fallen_leaf:
        
        UV irritation; Dust, wind, pollen
        
        Flies - Moraxella vector
        
        Woody pasture
        
        Trauma
        
        Mechanical transmission
        
        Overcrowding
  - - - Epiphora (Excess tears)
        
        Drainage failure
    - - Neovascularisation
      - Rupture
        
        Secondary infection
        
        Hypopyon - pus in anterior chamber
        
        Coning
      - Endophthalmitis - inflammation within eye
- - - - Mycoplasama felis
        
        :red_cross: well wall
        
        Variable morphology
        
        Diagnosis
        
        Diff Quik stain (Giemsa)
        
        Intra-cellular small basophilic coccoid structures
        
        Paler than chlamydial
        
        Peripherally located
      - Chlamydia psittaci var felis
        
        Primary pathogen of :eye:
        
        Prolonged shedding
        
        Clinical relapse
        
        Asymptomatic in 10% population
  - - - Feline infectious peritonitis (FIP)
        
        Wet FIP (effusive)
        
        Diagnosis
        
        FNA
        
        Reduced albumin:globulin ratio
        
        High protein, low cell count
        
        Direct immunofluorescence (IFA)
        
        Virus filled macrophages
        
        PCR
        
        FeCV mutation
        
        Dry FIP (non-effusive)
        
        Immunohistochemistry (IHC)
      - Toxoplasma gondii; FeLV; systemic mycosis
      - Lymphoma; diffuse iris melanoma
      - Not found in 50% of cases
    - - Pigmented, vascular component
        
        Iris, ciliary body, choroid