Please enable JavaScript.
Coggle requires JavaScript to display documents.
CHOLESTEROL medication :hamburger:, treatment with aspirin, Tylenol,…
CHOLESTEROL medication :hamburger:
lipoprotein
high density lipoprotein
takes cholesterol away
low density lipoprotein
deliver cholesterol
very low density protein
chylomicron
carrier
HMG CoA reductase inhibitor
statin
MOA
:no_entry:HMG CoA reductase
:arrow_down: intracellular hepatic cholesterol
:arrow_up: LDL-C receptor expression
:arrow_up: hepatic uptake cholesterol :smiley:
:arrow_down: VLDL
:arrow_down: TGs :smiley:
:arrow_up: PCSK9 level
:arrow_down: LDL-R expression :cry:
#
side effect
hepatotoxicity
:yellow_heart:
skeletal muscle
toxicity :weight_lifter:
rhabdomyloysis
myoglybinuria
renal toxicity
:blue_heart:
myalgia
myopathy
myositis
location: inside liver
BA SEQUESTRANTS 👨️👨
location
GI to liver
enterohepatic circulation
cholestyramine
bind BA intestine
:arrow_up: fecal excretion of BA
:arrow_down: BA
:arrow_up: BA synthesis
:arrow_down: intracellular hepatic cholesterol
:arrow_up: LDL-C receptor expression
:arrow_up: hepatic cholesterol uptake :smiley:
:arrow_up: HMG CoA reductase
attenuates LDL-C lowering action :cry:
side effect
GI disturb
flatulence
bloating
constipation
nausea
NPC1L1
ezetimibe
:no_entry: NPC1L1 transporter
:arrow_down: incorporation of cholesterol into chylomicron
:arrow_down: cholesterol delivery to liver
:arrow_down: intracellular hepatic cholesterol
:arrow_up: LDL-C receptor expression
:arrow_up: hepatic uptake cholesterol :smiley:
:arrow_up: HMG CoA reductase
attenuates LDL-C lowering action :cry:
minimal side effect
location surface of GI, brush border of small intestine
PSKC1 inhibitor :syringe:
alirocumab
monoclonal antibody to PCSK-9
:arrow_down: PCSK-9 activity
:arrow_up: LDL-R expression
:arrow_up: hepatic cholesterol uptake
side effect
allergic reaction
injection site
given SQ
give in combination with statin for max cholesterol sequestering effect
location: surface membrane of liver
PSKC1 protein made by liver
decrease hepatic cholesterol uptake
promote LDL-R degradation by lysosome
made all the time to regulate endocytosis of cholesterol
niacin receptors :horse:
niacin
MOA
:check: niacin receptor (Gi-coupled)
:arrow_down: Hormone sensitive lipase
:arrow_down: lypolysis
:arrow_down: release of fatty acid
:arrow_down: hepatic TG synthesis
:arrow_down: VLDL
1 more item...
liver uptake niacin
:no_entry: TG synthesis
location: fat cell, adipose tissue
side effect
increase prostaglandin
#
flushing
itching
dyspepsia :potable_water:
headache :face_with_head_bandage:
:candy: hyperglycemia
:yellow_heart: hepatoxicity
:bird: hyperuricemia
if combined with statin
#
#
treatment with aspirin, Tylenol, ibuprofen