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Leukograms - Coggle Diagram
Leukograms
endotoxic leukogram
acute effects (hours)
leukopenia
neutropenia
+/- lymphopenia
later effects
endotoxin + inflammation
normal to increased [WBC]
normal to increased [neuts]
+/- L shift
+/- toxic change
may not be evident when patient presents
transient
rarely seen in natural disease
+/- combo inflammatory leukogram
common patterns
steroid + inflammatory leukogram
marrow suppression masking inflammatory leukogram
additive effects
L shift w/ normal neut counts
suggests inflmmation
depletion of MNP
cells release fr/ MatNP
neut count consistent w/ either..
adequate balance b/w marrow delivery and tissue egress
snapshot in time may be increasing or decreasing
bone marrow failure/suppression leukogram
neutropenia
longer half lives components
+/- thrombocytopenia
+/- anemia
lymphocyte WRI
not dependent on marrow
inflammatory leukogram
characteristics
neutrophilic
+/- L shift
+/- toxic change
[neutrophils] vary widely
+/- monocytosis
+/- lymphopenia
mild inflammation
neutropenic
+/- L shift
+/- toxic change
species based differences are vital
overwhelming/uncompensated inflammation
dynamicism
pathogenic virulence
patient comorbidities
individual patient biologic variation
duration of illness
epinephrine leukogram
characteristics
mild-moderate leukocytosis
mature neutrophilia
:forbidden: toxic change:
2x URL :dog: :horse: :cow:
2-4x url :cat:
lymphocytosis
2x url
:cat: :horse: allowed
transient
steroid leukogram
characteristics
mild -moderate leukocytosis
mature neutrophilia
:forbidden: toxic change:
2x URL :dog: :horse: :cow:
2-4x url :cat:
lymphopenia
rare band cells possible from SNP
+/- monocytosis :dog:
+/- eosinopenia
often in combo with inflammatory leukogram
