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Lymphocytes: Leukocytes - Coggle Diagram
Lymphocytes: Leukocytes
production
produced in lymphoid tissues
lymph nodes
spleen
not housed in bone marrow
life span can be days to yars
pools
blood lymphocyte pool
circulating (CLP)
marginated (MLP)
lymphoid tissue pool
non-lymphoid pool
describing
data
lymphocytosis
lymphopenia
mechanisms
production
shift
neoplasm
apoptosis
external loss
process
stimulus
disease
mechanisms
chronic inflammatory lymphocytosis
lymphoproliferative neoplasia
physiological lymphocytosis
morphology
size matters
small :hot_pepper:
predominate
more mature
lymphoblasts :potato:
medium :carrot:
large :eggplant:
immature
or cow :cow:
still healthy
reflect state of maturation
:explode: reactive
increased
size
cytoplasmic volume
basophilia
irregular nuclear shape
B-cell acctivated
marker of Ag stimulation
lymphocytosis
causes
E
pinephrine
catecholamine effets
transient (<1h)
:cat: :horse:
shift from MLP to CLP
L
ymphoproliferative disorders
leukemia
lymphoma
viral or non-ciral origin
top differential for adults with unexplained chronic lymphocytosis
possibly chronic
I
nflammation
anecdotal esp for dogs
Ag stimulation?
can be difficult to deparate from epinephrine process
complex in :cat:
hyperthyroidism
toxoplasmosis
mycoplasmosis
renal disease
very low :arrow_down: on ddx list
H
ypoadrenocorticoidism
Addison's in :dog:
lack of glucocorticoid effects, decreasing lympho apoptosis
T
hymoma
altered lymphocyte trafficking
canine
E
hrlichiosis
Y
outh
<4mo
post-
V
accination
THEY LIVE
lymphopenia
steroids/stress
by far the most common cause
depletion/loss
chylothorax
GI loss
loss via lymphatics
acute bacterial/viral infection
shift from CLP to other pools
congenital
lymphoid hypoplasia/aplasia
CIDS in Arabians
decreased production
