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Microbial agents of neurological dz [Minor] - Coggle Diagram
Microbial agents of neurological dz [Minor]
Feline Parvovirus (FPV) :cat2:
Pathogenesis
Foetal malformation
Cerebellar hypoplasia
Late gestation
Kitten infected 2 wks before / after birth
Retina, optic nerves
Optic nerve atrophy; retinopathy
Hydranenephaly
Lymphoid tissue; bone marrow
Older cats
Viraemia
Lyphoid necrosis
GIT; bone marrow
Leukopaenia; DIC
Incubation: 2-10d
Equine herpesvirus-1 (EHV1) :horse_racing:
Pathogenesis
Late term abortion
9-11 months
Upper respiratory disease
EHV4
Meningoencephalitis
Mutant forms (uncommon)
Bovine ephemeral fever "3 day sickness" :cow2:
Insect-borne transmission
Tropical --> temperate (NT)
Epizoonotic outbreaks
Pathogenesis
Vasculitis
Synovial membranes
Muscle; tendon sheaths; skin
Hypocalcaemia
Viraemia
4-5days
Diagnosis
Clinical signs
:arrow_up: morbidity :arrow_down: mortality
Sudden onset and recovery (72hr) :hospital:
Biphasic fever; :arrow_down: milk production
Abortion - 2nd trimester
Lamness; nasal + ocular discharge; submandibular oedema
Serology
Rising titre
Treatment / control
Vaccines
Routine in endemic areas
Attenuated + inactivated
Cryptococcus
Pathogenesis
Cryptococcal rhinitis
CNS progression - haematogenous spread
Meningitis
Meningoencephalitis
Systemic mycosis
Source
Exogenous
Inhalation of basidiospores
C. neoformans - bird guana
C. gatti - dead plant material
Diagnosis
Biopsy, gram stain; nasal lavage; skin cytology
Feline Infectious Periotonitis (FIP) :cat2:
Pathogenesis
Mutated coronavirus
Greater intracellular macrophage tropism
Fatal inflammatory disease
Vasculitis + granulomatous phlebitits
Leukopaenia
T cell; NK cells :arrow_down:
Hypergammaglobilinaemia
Feline Immunodeficiency Virus (FIV) :cat2:
Pathogenesis
Latency - asymptomatic
B cell Lymphosarcoma
Lymphoid depletion
Abdominal structures
CNS
:arrow_down: astrocyte + microglial populations
Diagnosis
Ab titres
Long asymptomatic phase
Clinical signs
Opportunistic infections
leukopaenia
/Chronic/recurrent
Weight loss
Recurrent GIT dz
Caprine arthritis-encephalitis virus (CAEV) :goat:
Colostrum transmission
Pathogenesis
Encephalitis
kids 2-4mo
Arthritis
Osteocyte proliferation
Carpal joint swelling
Treatment/control
Euthanasia
Remove kids from dams
Feed colostrum heated at 1hr for 56DegC
Isolate from infected goats
Pasteurised milk