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Drug Metabolism in FASD and or post-trauma, Diphenhydramine (DPH),…
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Diphenhydramine (DPH)
N-Desmethyldiphenhydramine (aka demethyldisphenhydramine, DM-DPH)
N,N-Didesmethyldiphenhydramine (aka bis-demethyl diphenhydramine, BDM-DPH)
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"Diphenhydramine is in pregnancy category A – drugs which have been taken by a large number of pregnant women and women of child-bearing age without an increase in fetal malformations or other direct harmful effects on the fetus. At high doses, particularly during the third trimester, diphenhydramine can cause uterine hyperstimulation. Complications from this can include uterine rupture and placental abruption. In mothers taking high doses of diphenhydramine for prolonged periods, a withdrawal syndrome has been occasionally reported in the newborn. Animal studies involving high doses of diphenhydramine have shown fetal malformations can occur. A single human case report and a single animal study involving temazepam and diphenhydramine during pregnancy showed an increased risk of stillbirth and sudden infant death shortly after delivery. Diphenhydramine can be detected in the breast milk. In two studies involving diphenhydramine use during breast feeding, babies were irritable, slept more or less than controls." -https://www.sciencedirect.com/topics/chemistry/diphenhydramine
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