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Atropine & Hyoscimine - Coggle Diagram
Atropine & Hyoscimine
Treatment
ABC
Antidate
Physostigmine
Antagonize & Peripheral & Central action
Pilocarpine
Antagonize & Peripheral action only
Decontamination
Gastric lavage
Activated charcoal
Emesis
Symptomatic treatment
Positive sedative
Ir-diazepam
Ether
Barbitorate
Negative
Caffeine or coramine
Constipation>>enema
Catheter>>retention
Sipping in mouth
Cold compressor>> Hyperthermia
C/P
Peripheral
Tachycardia & Tachypenia
Urine retention & Constipation
Hot dry skin & Dry mouth
Dilated pupil
Increase body temperature
Diminshed bowel sound
Bitter taste
Central
Initial stimulation for 1 hour
Irritability & Restlessness
Staggering gait
Agitation & Hallucination
Purpouseless movement
Convulsions
Secondary (0) stage
Coma / Stuper / Drowsy / Death due to .. Respiratory paralysis
Rhabdomyolysis
Increase energy
Decrease O2
Mechanism of toxicity
Atroine & Hyosciamin
Peripheral
Competitive
Antagonist Ach at cholinergic nerve ending
Central
Stimulation
Inhibition
From above downwards especially Respiratory center
Hyoscrine
Central with Mild peripheral action
Depression from start
No stimulation
Therapeutic uses
Atropine & Hyoscimine
Treatment of bronchial asthma
Relief renal & biliary colic with apiate
Antidote
Digitalis
Aconite
Organophosphorus
Morphine
Preanethetic
Stimulation respiratory center
Bairpassage secretion & salivation
Prevent vagal inhibition of heart
Hyoscimine & Scopolamine
Treatment Parkinsonism (Inhibition motor cortex)
Truth serum or lie detector
Prevent vagal inhibition of heart
P.M picture
Nofroth
Asphyxia
Seed