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Neuropathology [Response to injury] - Coggle Diagram
Neuropathology [Response to injury]
Malacia
Massive necrosis of neurons
Cyst formation; oedema; vascular proliferation
Highly susceptible
Small energy stores + high metabolic demands
Ischemia
:red_cross: regeneration
Healing
Healing - astrocyte proliferation (Astrogliosis)
Absent fibroblasts
:red_cross: collagen fibres
Cell processes - swelling, division + proliferation
Satellitosis
Oligodendrocyte Swelling and hypertrophy
Around injured neurons
Acidophilic neuronal necrosis (acute necrosis)
:arrow_double_down: ATP generation
Eg. cyanide/CO poisoning; hypoglycemia
Necrotic neurons removed via neurophagia
Activated microglia
Viraemia
Reactive proliferation
Microglial nodules
Recruited macrophages (Gitter cells)
Wallarian degeneration
Axonal damage
Trauma
Compress / sever spinal cord
Degenerate distal to injury site
Central chromatolysis
Nucleus + chromatin pushed to cell periphery
Demyelination
Oligodendrocyte damage
Primary / secondary
Viral infection eg. Canine distemper ; ischaemia
Remyelination
Spongy change
Vacuolation + microcavities
Common injury pattern
Oedema
Meningoencephalitis
Spongiform encephalopathy :dog2:
Demyelination
Spongy degeneration
Hereditary autosomal Recessive Disorder :dog2:
Artefact