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Degenerative Disease: Neuropathology - Coggle Diagram
Degenerative Disease: Neuropathology
common lesions
subtle
bilateral symmetrical
malacia/necrosis +/- hemorrhage
selective loss
neuronal
axonal
myelin
status spongiosus
astrogliosis
brain atrophy if late
multisystemic disorders
Kerry blue terrier
striato-nigral and cerebello-olivary degeneration
chromatolysis/loss of motor neurons
caudate nucleus
cerebellar cortex
cerebellar abiotrophies
autosomal recessive trait
Arabian :horse:
affects...
Purkinje cells
granule cells
spinal cord neuro-axonal dystrophies
equine degenerative myeloencephalopathy
affects proprioceptive system neurons
manifests as SC disease
ataxia
acquired or heritable
vitamine E deficiency
genetic facotes
breeds
Morgans
Saddlebreds
anatomic changes
spheroids affecting distal axon segment
distribution
proprioceptive nuclei of brainstem and SC
brainstem nuclei at obex
spinal cord nucleus
characteristics
often genetic
familial clustering
young animals
late onset is possible
slow disease progression
myelin disorders
i.e. leukodystrophies
globoid cell leukodystrophy
form of sphingolipidosis
autosomal recessive in some obscure- ass terriers
galactosylceramidase deficiency
accumulation of cytotoxic galactoceramide
Schwann cells
leads to necrosis
oligodendrocytes
impaired myelin turnover
macrophages
foamy appearance
hypomyelination
hereditary or congential
BVDV
classical swine fever
border disease virus
often recover
TSEs
BSE
Scrapie
CWD
transmissable mink encephalopathy