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Toxic Causes: Toxic/Metabolic of Disease:Neuropathology - Coggle Diagram
Toxic Causes: Toxic/Metabolic of Disease:Neuropathology
heavy metals
lead
cerebro-cortical necrosis
young animals more at risk
birds
"plumbism"
trumpeter swans
no brain lesions
bald eagles
lesions
brainstem
cerebellar peduncles
cerebellum
eye
heart
fibrinoid arteriolar necrosis
hemorrhage
ischemia
infarction
arsenic
mercury
treated seed grain
:pig: :cow:
organic and inorganic compounds
no lesions
organophosphates
cyanide
nitrate/nitrite
fluoroacetate
carbon monoxide poisioning
NaCl
caused by cascade of pathological changes
imbalance b/w
brain osmolarity
astrocyte regulated
plasma osmolarity
kidney regulated
hypo-osmotic brain edema
brain swelling
circulation impeded
cerebral cortical laminar edema
neuronal necrosis
malacia
:pig: :cow:
selenium
toxic plants
plant-induced storage diseases
Centaurea solstitialis
C. repends
nigro-palladial encephalomalacia
microbial toxins
focal symmetrical encephalomalacia
entermotoxemia
C. perfrigens
type D
leukoencephalomalacia
fumonisin B1
moldy corn poisoning
lesions
vascular necrosis
vasogenic edema
widespread multifocal cerebral white matter malacia
bilateral but not symmetrical
+/- hemorrhage
Fusarium
spp. :mushroom:
:horse:
botulism
tetanus
microbial toxins
focal symmetrical encephalomalacia
grey and white matter affected
enteric overgrowth of specific toxinogenic bacteria
E. coli
"edema disease" in :pig:
C. perfringens
type D
"pulpy kidney disease"
:sheep: :goat:
widespread vascular damage
vasgenic edema
cytotoxic component
bilateral symmetric grey and white necrosis
clinical signs
CNS impairment
incoordination
staggering gait
head tilt
convulsions
recumbency
facial and eyelid edema
sudden death
lesions
edema
gastric submucosa
mesentery
mesocolon
larynx
serous effusion
abdomen
thorax
maybe fibrin in the mix
brain
brainstem malacia
rarely lesions
possible to have none
