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Metabolic Causes: Toxic and Metabolic Diseases: Neuropathology - Coggle…
Metabolic Causes: Toxic and Metabolic Diseases: Neuropathology
hypoglycemia
primary E failure
delayed onset degeneration and necrosis
most susceptible neurons
cerebral cortex
hippocampus
morpho
neuronal degeneration
mitochondrial swelling
histo
hypereosinophilia of neurons
may look like autolysis
causes
insulinoma
insulin overdose
hypoglycemia fatty liver syndrome
neonatal toy dog breed
1w old piglets
incapable of gluconeogenesis
hepatic encephalopathy
endogenous intoxication
insufficient detoxification of ammonia
ammonia passes BBB readily
used by astrocytes to synthesize glutamine
glutamine accumulation leads to...
cytotoxic edema
myelin damage
status spongiosus at grey and white matter jxns
alzheimer type II astrocytes in :horse:
causes
hepatotoxic plants
liver cirrhosis
congenital portosystemic shunts
clinical signs
worsen after a meal
ataxia
head pressing
increase blood ammonia
lysosomal storage diseases
lysosomal hydrolase deficiencies
accumulations of
shingolipids
glycolipids
oligosaccharides
mucopolysaccharides
autofluoresent lipoproteins
inherited
autosomal recessive
acquired
plant poisoning
amphophilic drugs
types
alpha-mannosidosis
grazing livestock
causes by swainsonine
locoweed spp.
clinical signs
imbalance
ataxia
hypermetria
intention tremors
staggering
depression
Batten's disease
accumulations of lipofuscin-ceroid in neurons
