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Protozoal Infections: Inflammation: Neuropathology - Coggle Diagram
Protozoal Infections: Inflammation: Neuropathology
pathogenesis
CNS tissue reacts as if viral infection
immunosuppression req'd
life cycle
DH
intestinal
asymptomatic
shed infective oocysts
IH
symptomatic or asymptomatic
asexual replication in vascular endothelium
ischemia
vascular lesions
common protozoans
Sarcocytis neurona
:horse:
DH
oppossum
IH
raccon
lesion
caudal brainstem
cervical and thoracic spinal cord
perivascular cuffs
lymphocytes
macrophages
multinucleated giant cells
eosinophils
edema
ischemia change
may find organisms in lesions
free
encysted
endothelial cells
macrophages
neurons
atrophy of peripheral nerves from affect area of SC or brainstem
muscular atrophy
causes equine protozoal myeloencephalitis
CSF preferred for diagnosis
Sarcocystis calchasi
pigeons
Toxoplasma gondii
:cat: :goat: :dog: :man:
DH
cat
IH
atypicals
dogs
humans
goats
also cats?
cat's prey animals
lesion
random malacic foci across grey and white matter
large protozoal cysts
histiocytic inflammatory process
protracted infection
granuloma formation
protozoal cysts may not be apparent
tacyzoites on IHC
infect
endothelial cells
astrocytes
neurons
33% of cases have CNS involvement
causes toxoplasmosis
Neospora caninum
:dog: :cow:
DH
dog intestine
IH
cattle
may cause abortions
atypical
dogs
CNS
muscles
infect
endothelial cells
astrocytes
neurons
clinical signs
hind limbs
myositis
polyradiculoneuritis
granulomatous
necrotizing
lesions
brain and spinal cord
marked inflammation
granulomatous
eosinophilic
protozoal cysts
hypercellularity
perivascular uffinf
