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Francisella tularensis - Tularemia - Coggle Diagram
Francisella tularensis
- Tularemia
diagnosis
culture isolation is confirmative
growth and habitat
preferential infection of cells of reticuloendothelial system
small white colonies on blood agar
fluorescent Abs used
biochemical characterization is difficult
do not attempt to isolate outside of BSL-3
postmortem in wildlife and livestock
ELISA and hemagglutionation
reportable
characteristics
gram neg coccibacilli
not motile
no spores
very low dose needed
only 1 organism to cause infection and disease in 40-50% of animals
infection and pathogenesis
causative agent of tularemia
acute febrile dz
gains entry though
mucosa
skin breaks
biting flies
ticks
inhalation
ingestion
granulomatous lesions on visceral organs
necrosis
LNs of the head and neck involved
painful swellings
low infectious dose
clinical disease
dogs
subclinical
self-limiting
many show seroconversion
signs
fever
pustules at site of entry
anorexia
cats
nonclinical in some animals
signs
LN swelling
fever
oral ulcerations
depression
icterus
rabbits
horses
nonclinical in some
signs
fever
LN swelling
oral ulceration
depression
icterus
cattle
seroconversion
little info on clinical dz
sheep
fever
difficulty breathing
rigid gait
diarrhea
weight loss
abortions
humans
small papule at site of entry
fever
LN swelling
pneumonia
treatment
Abx responsive
1-3w
early intervention most successful
dogs and cats
streptomycin
amoxicillin
gentamycin
rabbits
streptomycin
tetracycline
widlife
streptomycin
tetracycline
preventative
tick control
vaccination for human available