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Bacterial: Inflammation and infections: Neuropathology - Coggle Diagram
Bacterial: Inflammation and infections: Neuropathology
bacterial meningitis
host response
inflammatory cells
reactive oxygen
astrocytes
microglia
may cause injury
enter through bloodstream
can enter ventricular system
release proinflammatory and toxic compounds
pleocytosis
increased BBB permeability
suppurative and meningoencephalitis
+/- choroiditis
secondary to generalized bacteremia
multiple organs seeded
disease of young/immunocompromised animals
failure of passive transfer
severe combined immunodeficiency
E. coli
Streptococci
primary infection may be difficult to find
lesions
cloudy meninges on ventral aspects
altered by inflammatory exudate
neutrophils in subarachnoid space
may be abacteric
secondary changes
brain swelling
edema
hydroencephalus
exudate may obstrute CSF flow
ependymitis
periventricular encephalitis
choroiditis
superficial hemorrhage may be present
abscesses
hematogenous seeding
often associated with larger septic emboli
thromboemboli
arterial embolization
infarction
Streptococcus
spp.
species
New World camelid :camel:
white tailed deer :deer:
ruminants
rare in cats and dogs
walled off by fibrillary astrocytes
thrombotic meningoencephalitis
Histophilus somni
feedlot cattle :cow:
lesion
multifocal...
vasculitis
thrombosis
results in
necrosis
hemorrhage
1-3cm foci randomly scattered
pus and fibrin exudate
necrosis (malacia)
concurrent heart and lung lesions
fibronecrotic vasculitis with seondary thrombosis
bacteria present in macrophages
neural listeriosis
Listeria monocytogenes
short
motile
rods
g+
three disease syndromes
abortion
septicemia
neonates
encephalitis
ruminants
swine
horses
new world camelids
pathogenesis
inadequate fermentation of silage
enters through trigeminal n.
entry points
defects in buccal mucosa
erupting teeth
exposed dental pulp
intra-axonal migration to the brainsteam
pons region encephalitis
can extend from oculomotor nuclei to cervical spinal cord
listeric rhombencephalitis
lesions
brainstem
gross
meningeal congestion
turbid CSF
pinpoint yellow to red soft parenchymal foci
microscopic
located in leptomeninges to ependyma
non-supprative meningitis
non-supprative perivascular cuffing
parenchymal microabcesses
neutrophills
may ID organisms
