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Polioencephalitic Diseases: Lytic Infections: Direct Damage: Viruses:…

- - - - upper alimentary
      - respiraotry
      - tonsils
    - - nervous tissue
    - - acute encephalopathy/encephalitis
        
        neuronal lytic infection
        
        very young dogs
        
        rapid CNS spread
        
        +/- inflammation
      - subacute demyelinatng encephalitis
        
        glial lytic infection
        
        most common
      - delayed onset encephalitis
        
        "old dog encephalitis"
        
        neuronal viral persistence
      - subacute encephalitis
        
        predominant non-neuronal infection
        
        lesions
        
        white matter
        
        cerebellum
        
        pons
        
        mesencephalon
        
        medulla
        
        spinal cord
        
        3-10w post-infection
        
        loss of myelin
        
        severe inflammation
        
        glial inclusion bodies
        
        astrocyte fusion
        
        +/- malacia