Please enable JavaScript.

Coggle requires JavaScript to display documents.

Poliomyeloencephalitic Infections: Lytic Infections: Direct Damage:…

- - - - CSF serology
      - virus isolation
      - PCR
      - IHC
- - - - ganglioneurits
      - CNS
  - - - maximal involvement
        
        pons
        
        hypothalamus
        
        hippocampus
      - virus inclusions
        
        Purkinje cells in herbivores
        
        neurons of hippocampus
    - - cranial nerve introduction is less rapid than direct brainstem intro
      - paralysis may present
    - - evades immune surveillance
  - - - cerebelum
      - brainstem
  - - - paralytic for
        
        "dumb" form
      - encephalitis form
        
        limbic system targeted
        
        "furious" form
- - - - "milder" form
  - - - olfactory lobes to lumbar SC
      - most severe in
        
        brainstem
        
        cerebellum
        
        cevical spinal cord
      - motor neuron necrosis in spinal cord
      - mononuclear ganglionitis