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Lyme Disease in SA - Coggle Diagram
Lyme Disease in SA
clinical signs
develop 2-5mo after tick bites
fever
inappetences
lameness
1 or more joints involved
shifting leg lameness
1st joint effected is closest to tick bite
if nephritis develops....
30% are polyarthritic
weight loss
inappetence
pu/pd
thin BCS
dehydrated
peripheral edema
pleural effusion
ascites
hypertension
retinal detachment
joint effusion
generalized lymphadenopathy
pathogenesis
synovial tissue
T cells
B cels
plasma cells
Mo cells
joint fluid :check:
neutrophils :check:
immune complexs
complement
Th1 cytokines
lyme nephritis
glomerulonephritis
deposition of Ag-Ab complexes in basement membrane
leads to protein loss in urine
worsens over time
breed specific
29% labs
20% golden retrievers
specific to dogs
prevention
flea-tick prevetation annual
tick removal within 24h
vaccination
Borrelia burgdorferi
most commonly reported vector-borne dz in US
common in dogs, unrecognized in cats
epidemiology
dog seroprevalnce ranges from 6.5-85%
based on POC Ab tests
85% of cases in eastern coastal state
10% MN/WI
4% NorCal
5-10% develop clinical signs
most serious consequence is Lyme nephritis
ultimately fatal
rare
transmission
black-legged tick
min 48hr after tick attachment
B. burgdorferi
can't disseminate to tick salivary gland until they put on their "spring jacket"
Osp C
winter coat is Osp A
diagnosis
serology
VlsE "variable major protein-like expressed"
C6
invariable region
Osp A
vaccinated
Osp C
early infection
Osp F
chronic infection
treatment
antibiotics for 28d
past this is unnecessary and ineffective
evidence of bacterial persistence
