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Defense condition against bacterium - Coggle Diagram
Defense condition against bacterium
Invasion via the natural barrier, the skin
Recognition via PRRs (Pathogens Recognition Receptors)
Extra
cellular
TLRs
(Toll-Like Receptors)
Recognize proteins, nucleic acids and glycan
CLRs
(C-type Lectin Receptors)
Recognize glycan from the wall of fungi/bacteria
Intra
cellular
NRLs
(NOD-Like Receptors)
AIM2
Detect viral and bacterial DNA
Form inflammasome
NLPRs
Recognize bacterial, viral, parasitic and fungal PAMPs
NOD1/2
Recognize bacterial peptidoglycan
RLRs
(RIG-I-Like Receptors)
Cytoplasmic sensors of viral RNA
Complement system
Alternative
Lectin
Classical
Activation of the innate immune system
Neutrophils
Rolling
Diapedesis
Natural Killer cells
APCs (Antigen Presenting Cells)
Dendritic cells
Macrophages
Activation of the adaptive immune system
Humoral
immunity
TH-2
Activation of Naive B-cells
Maturation of B cells
Plasma cells
Memory B cells
Memorize the pathogen for a faster antibody production for further infections
MHC-II
binds to TCR (
CD4+
) -> extracellular (bacteria)
MHC-I
binds to TCR (
CD8+
) -> intracellular (viruses)
Cell-mediated
immunity
MHC II
Dendritic cells migrate to the secondary lymph nodes
Expression of B7 receptor
Activate naive T cells
Signal 1
: TCR to MHC II -> CD4;
Signal 2
: Costimulatory B7 receptor binds to CD28 on the naive T cells;
Signal 3
: IL-12
Activation of T cells adherent to CD4
TH-1
1 more item...
TH-2
2 more items...
TH-17
2 more items...
Binary Fission