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cell injury 2 - Coggle Diagram
cell injury 2
MORPHOLOGY OF REVERSIBLE CELL INJURY
Hydrophic change:
accumulation of water in cytoplasm,
cloudy swelling,
vacuolar degeneration,
completely reversible change
2.Hyaline change:
3.Mucoid change:
Mucus like change by mucin
Fatty change:
intracellular deposits
glassy,
homogenous,
pink deposits of proteinaceous material,
intracellular and extracellular hyaline
MORPHOLOGY
1.the study of the forms of things.
2.a particular form, shape, or structure.
ACCUMULATION OF OXYGEN DERIVED FREE RADICALS
(OXIDATIVE STRESS)
Free radicals have single unpaired electron in an outer orbit and are highly reactive.
Superoxide oxygen (O’2)
Hydrogen peroxide (H2O2)
Hydroxyl Radical
others
Nitric oxide,
Peroxynitrite,
Halide reagent, etc
CYTOTOXICITY OF FREE RADICALS
Lipid peroxidation:
leads to membrane damage and
destruction of organelles
Oxidation of proteins:
this causes fragmentation of polypeptides
DNA damage:
breaks single strands of nuclear and mitochondrial DNA,
which can lead to malignant transformation of cells
Cytoskeletal damage:
interacts with cytoskeletal elements and
interferes with ATP production