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Malignant catarrhal fever (MCF): Mucosal Diseases: Ruminant Multisystemic…
Malignant catarrhal fever (MCF): Mucosal Diseases: Ruminant Multisystemic Disease
malignant catarrhal fever (MCF)
:cow: :deer: :water_buffalo:
systemic vasculitis
viral infection of vascular endothelial cells
widespread necrotizing vasculitis
ischemic tissue damage
can affect any/all organ systems
etiology
African form
North American form
natural hosts carry virus w/o clinical dz
disease in :cow:
low morbidity
100% mortality
single animals or outbreak
history of exposure to sheep
6-9mo lambs
zoos
dead end hosts
transmission
unknown in cattle
something to do with sheep, direct h=contact not needed
incubation period
NA form 3-10w
African form 1-2w
clinical syndromes
head/eye form
most common
kertoconjunctivitis
corneal inflammation
edema
generalized/acute form
keratoconjuctivitis
resp dz
skin lesions
ulcerations
muzzle
hooves
horns
thickened, cracked skin
hooves, horns may slough
meningoencephalitis
progressive CNS signs
lymphadenopathy
GI disease
diarrhea
oral ulcerations
ptalism