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Hemorrhagic Disease: Mucosal Disease: Multisystemic Disease in Ruminants -…
Hemorrhagic Disease: Mucosal Disease: Multisystemic Disease in Ruminants
clinical syndromes (BTV/EHDV)
systemic vasculitis
BTV
Bluetongue virus
clinical syndromes
in :sheep:
fever
facial edema
GI lesions
stomatitis
ptalism
tongue cyanosis
diarrhea
respiratory dz
nasal discharge
pulmonary edema
+/- secondary bacterial pneumonia
musculoskeletal system
coronitis
laminitis
myopathy
repro system
in utero
fetal infection
organogenesis disruption
teratogenesis
abortion
weak lambs
in :cow:
same as sheep
ptalism
muzzle hyperemia/necrosis
dermatitis
congenital defects
overview
reported in camelids, cervids, cattle with variable clinical signs
most common in sheep
sheep
cattle
EHD
epizoonotic hemorrhagic disease virus
overview
cattle may be host, with mild dz
:sheep: :goat: maybe?
most severe dz in :deer:
multiple serotypes
1 & 2 most common in US
clinical syndromes
:deer:
peracute form
high fever
respiratory distress
severe edema of the head and neck
sudden death (8-36h)
may have no signs
acute form
same as peracute
GI tract
2 more items...
widespread petechial hemorrhage
high mortality
chronic
recovery after several weeks
blood flow to hoof disrupted
lameness
slough hooves
chornic GI ulcers/scarring
weight loss
starvation
:cow:
mild, subclinical
oral ulcers
decreased feed intake
coronitis
lameness
decreased milk production
deer
transmission
blood-sucking arthropods
midges
Culicoides imicola
Asia
Africa
Europe
Culicodes sonorensis
US
incubation period 2-10d
pathophysiology
virus replicates in wide variety of tissues
systemic vascular endothelial cells
vasculitis
petechiae
edema
necrosis of epithelial and mucosal surfaces
