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Ticks and Rickettsial Disease: Anaplasmataceae in SA - Coggle Diagram

- - - - splenomegaly
      - fever
      - thrombocytopenia
      - lameness
      - lymphadenopathy
- - - - 8-20d incubation
      - 1-4w long
      - organism replicates in reticuloendothelial tissue
        
        spleen
        
        LNs
      - clinical signs
        
        platelet dysfxn
        
        thrombocytopenia
      - may recover in 2-4w
    - - months to years
      - E. canis sequestered to spleen
      - Ag variation evades host
      - recover or become chronic
    - - uncommon
      - severe
      - clinical signs
        
        pancytopenia
        
        bone marrow hypoplasia
        
        marked granular lymphocytosis
        
        monoclonal cammopathy
        
        misdiagnosis of leukemia or plasmacytoma
        
        death
        
        hemorrhage
        
        secondary infection
    - - lethargy
      - inappetence
      - fever
      - lameness
      - weight loss
      - bleeding
        
        epitaxis
        
        petechiae/ecchymoses
        
        neuro signs
        
        hyphema
        
        dyspnea
        
        can occur anywhere
    - - thrombocytopenia
      - hypoalbumenia
      - hyperglobulinemia
        
        usually polyclonal
      - increased clotting signs
      - pancytopenia in chronic cases
      - tests
        
        IFA :first_place_medal:
        
        Idexx SNAP 4Dx
        
        immunoblot
        
        must be 21d post infection
        
        can differentiate fr/ E. canis and E. ewingii
        
        PCR
        
        best in acute phase
        
        morulae on CBC
    - - severe leukopenia
      - severe anemia
      - increase aPTT
    - - German Shepherds
      - Doberman Pinschers
- - - - uveitis
      - petechiae