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Congenital Malformations: Neuropathology - Coggle Diagram
Congenital Malformations: Neuropathology
usually subtle
brain development for dum-dums
from neural plate to neural tube
tube becomes ventricles
crest cells become, like, the brain
etiology
primary
spontaneous
inherited
single point mutation
chromosome abnormalities
secondary
exposure to teratogens
intrauterine
toxic chemicals from drugs or plants
hyperthermia
ionizing radiation
vitamin deficiencies
hypothyroidism
Schmallberg virus
variety of massive brain malformations
emerging
diagnostic strategy
clinical signs shortly after birth
often not progressing
possible improvement
may be visible at external exam
types
meningeal melanosis
incidental
neural tube closure defects
anencephaly
prosencephalic hypoplasia
cranium bifidum w/ meningocele
meningoencephalocele
meningomyelocele
forebrain induction defects
holoprosencephaly
fused hemispheres
neuronal migration disorders
lissencephaly
smooth brain
normal in birds and rodents
pachygyria
polymicrogyria
proliferation disorders
microcephaly
encephaloclastic defects
porencaphaly
hydraencephaly
caudal fossa and spinal cord defects
cerebellar hypoplasia
feline parvovirus
infected queen during pregnancy
granule cells targeted and killed
impaired migration of neurons and glial cells during cerebellar dev
fatly stratification
intrauterine parvovirus infection
dysplasia
congenital hydrocephalus
most common
brachocephalic breed standard
arachnoid cysts
