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Microscopic lesions, ischemia: Malformations: Neuropathology - Coggle…

- - - - neurons are higher demand than oligocyte
      - most susceptible to ischemia
        
        large pyramidal cells of 3,5,6 in cerebral cortex
        
        hippocampal pyramidal cells
        
        purkinje cells
  - - - depends on reperfusion
    - - 1-12h no change noticeable under light microscopy
      - 12h acidophilic neuronal necrosis in sensitive cells
      - 12-24d neutrophil infiltration
      - 1-3d macrophages, foamy macrophages
      - 1-2w reactive astrocytosis
      - months later - cavitation, astroglial lining, scarring