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Microanatomy of CNS: Neuropathology - Coggle Diagram
Microanatomy of CNS: Neuropathology
glial cells
barriers
BBB
oligodendrocytes
large amount of cytoplasm
often in a line
aka Schwann cells in PNS
make myelin sheaths
stained with luxol fast blue
small nucleus
pericytes
endothelial cells
mural cells
embedded in brain tissue
blood-CSF barrier
fenestrated endothelial cells
embedded connective tissue
choroid plexus and cimcumventricular organs
astrocytes
may need IHC GFAP to identify
support conduction
clean-up
immune resposne
MHC II on surface in cases of inflammation
foot processes of BBB
microglia
derived from same cell type as macrophages and act like them
cannot unequivolcally identify without IHC
Iba1
ependymal cells
Vim +
cuboidal single layer cells
derived from neuroectodermal cells
GFAP -
ciliated
choroid plexus epithelial cells
specialized ependymal
meningiomas can arise from these
involved in BBB structure
gray matter
neurons
sometimes have prominent nucleolus
large
filled with
Nissl substance
involved in injury
stained with Cresyl violet
spinal motorneurons and other metabolically active cells have prominent Nissl
free ribosomes and tracts of protein synthesis
stained with silver stain
postmitotic (non-regenerative) cells
neuropil
gray matter parenchyma
intricate framework of glials, axons, dendrites, etc
requires EM to see
white matter
myelinated axons
highly vascularized
