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Drugs for Immune suppression - Coggle Diagram
Drugs for Immune suppression
Drugs
Calcineurin inh.
Binds
FKBP12
Tacrolimus
MOA: indirect inh. Of calcineurin
Binds
cyclophillin
Cyclosporin A.
Proliferation
signal inh.
(PSI’s)
MOA: bind immunophilin FK506 binding protein 12, this blocks target of rapamycin(mTOR), this inh. IL-driven T-cell, B-cell and Ab proliferation
Sirolimus
Everolimus
Temsirolimus
Rapamycin
Glucocorticoids
Prednisone
Prednisolone
Dexmethasone
Cortisone
Cytotoxic agents
Methotrexate
Binds DHFR, which inh. DHFR (polyglutamated by FPGS)
Leucovorin reversed
Sulfasalazine
M
bacteria
Sulfapyridine
Mesalazine
Azathioprine
Gets incorperated into DNA and messes it up
Cyclosphamide
Inc. lysosome/endosome pH, this dec. MHC II loading and T-cell activ.
Leflunomide
Prodrug
Terflunomide
Inh. Pyrimidines
Hydroxychloroquine
Mycophenolate
mofetil
inh T/B cell poliferation, from inh. IMPDH (this makes purines)
Thalidomide
VERY teratogenic
Antibodies
Anti-lymphocyte
Anti-thymocyte
ALG
ATG/ATGAM
Pooled Ig’s
from humans
IGIV
Hyperimmune
immunoglobine
Prevent mother from
exposure to Childs blood
RhoGAM
JAK/STAT
pathway
JAK inh.
Baricitinib
MOA: inh. JAK1/2 >TK2, and JAK3
Tofacitinib
MOA: inh. JAK 3
PDE4 inh
Apremilast
Crisaborole
IL-6R
targeting antibodies
Tocilizumab
Sarilumab
IL-2 receptor
antagonist
Basiliximab
IL-17
Secukinumab
Ixekizumab
Brodalumab
IL-12/23
Ustekinumab
TNF-αi
Adalimumab
Etanercept
Inflixamab
Certolizumab
Golimumab
Interupting APC
presentation to t-cells
Abatacept
Belatacept
B-cell inactivation
Alemtuzumab
BAFFi
Belimumab
CD20
Rituximab
