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Brain Edema: Neuropathology - Coggle Diagram
Brain Edema
: Neuropathology
increased brain tissue water content
types
vasogenic
most common
loss of BBB fxn
damage to...
basement membrane
endothelial cells
pericytes
astrocytes
separation of inter-endothelial tight jxn
formation of transendothelial channels
increased permeability
high protein content
distribution depends on affected vessels
localized
tumor
abscesses
hematoma
truma
infarct
generalized
trauma
toxins
generalized infections
vasculitis
cytotoxic and vasogenic often in combo
primary endothelial cell injury
vasogenic edema + decreased tissue perforation
tissue hypoxia from edema
cytotoxic component develops from hypoxia
primary astrocyte insult
cytotoxic edema + tissue volume expansion
expansion and edema lead to vascuar compression
endothelial injury develops from compression
laminar blood flow loss
vasogenic component develops
cytotoxic
damaged ATP-independent ion pumps
hypoxia
toxins
metabolic disease
intracellular fluid accumulation in astrocytes, neurons, oligos
normal vascular permeability
hypo-osmotic
water intoxication
salt toxicity
swine
bovine
hydrostatic/interstitial
elevated intraventricular hydrostatic pressure
leaked fluid into periventricular white matter
accompanies hydrocephalus
status spongiosus development