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Rabies - Coggle Diagram
Rabies
pathogenesis
replication
mm
neurons
attachment w/ g glycoprotein
use receptors at neuromuscular jxns
nAChR for entry into mm cells
neurons
NCAM for adhesion into neuron
P75 for entry
virus hidden from immune response
spread into CNS
ipsilateral entry to bite
contralateral spread
no regional preference in the brain
incubation 14-90d!
suggests time-dependent movement
no viremic phase
no viremic phase
in brain
no gross signs
infiltration by mononuclear cells
non-supprative encephalomyelitis
defective neurotransmission
behavior dysfxn
Negri bodies
signs
excessive drooling
nerve-muscular paralysis
unvaccinated
exposure
bite wound
dog bite
profound behavior changes
transmission
bite/scratch
mucous membrane exposed to infected saliva
rare aerosol transmission
organ transplant
shedding
moves anterograde via peripheral nerves to
salivary glands
viral budding
adrenal cortex
pancreas
dogs
1-5d before signs
10d observation period
cats
1-2d before signs
3d after signs
phases
prodromal
often missed
2-3d in dogs, 1-2d cats
opposite personality/behavior than normal
furious phase
replication is occuring in limbic region
paralytic (dumb)
laryngoparalysis
earliest LMN signs
droped jaw
drooling
frothiness
death in 2-4d
replication is occurring in the neocortex
death
3-5d after signs present
characteristics
affects all warmblooded animals
high
skunks
raccoons
bats
cattle
moderate
dogs
cats
sheep
goats
horses
monkeys
low
birds
primitive mammals
worldwide distribution
dogs are most important reservoir for human infections
diagnosis
histopath
negri bodies
poor diagnostic
pervascular cuffing
direct fluorescent Ab test
exposure management
pet exposure
availability of biting animal
if biting anima is vaccinated
10d observation
vaccination status
vaccination
revaccinate
45d observation
cleanse wound
unvaccinated
euthanize
vaccinate
isolate for 6mo
human exposure
biting animal
do NOT vaccinate
10d observation
if unvaccinated
must be in secure location
if signs detected
euthanasia
brain testing
in vaccinated
can be obsreved in home
if signs not detected
released to owner
Minnesota
skunk reservoir
excrete high queantities of virus in saliva
prolonged incubation period
long-term subclinical infection
very aggressive when signs develop
prevention
vaccination
at 3mo of age
maternal Abs
annual
triannual
inactivated vaccine
takes 28d for immunity