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RBCs: Birth, Function, Death - Coggle Diagram
RBCs: Birth, Function, Death
erythopoiesis
arise from common progenitor
myeloid stem cells
production
erythropoietin
stimulated by hypoxia (pO2)
negative feedback loop
kidney source
if the kidney is diseased then...that'ssss baaaad.
colony stimulating factors
stem cell factors
maturation
think of as a pyramid
rubriblast
differentiates into prorubricytes
differentiates into rubricytes
mature into
metarubricytes
mature into
reticulocytes
reserve post-mitotic pool created
nuclei extruded
timelines
rubriblast to reticulocyte is 5 days
+2 days from reticulocyte to RBC
2-5d in hypoxia
color changes from blue to red
directly reflects change in [HgB]
divides
divides multiple times
cells produce more hemoglobin (HgB) as they mature
cells decrease in size
cells produce more hemoglobin (HgB)
each point of maturation divides into more future RBCs
function and metabolism
transport HgB
composed of globin chanins and Fe-containing heme
function
HgB
must be in reduced (Fe2+) form to bind oxygen
Fe3+ :frowning_face:
methemoglobin
cannot bind oxygen
mucuous membranes may appear cyanotic
blood will be brown
Fe metabolism
Fe2+
DMT1
ferrotportin 1
blood
transferrin into
liver :recycle:
hepcidin
5 more items...
:arrow_left: erythroid marrow
into blood :checkered_flag:
downregulated in inflammation
:arrow_left: into epithelials
from diet
death (RIP)
by cell type
RBCs
by species
horse 145d
cat 70d
cow 160d
dog 120d
60 days
neutrophils
shortest
first thing to go down in response to bone marrow suppression
6 hours
platelets
6 days
destruction
rate limiting step is conjugation of bilirubin
you zoned out. Something about recycling and the liver.
