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Intro to Inflammation and Infections of the nervous system: Neuropathology…
Intro to Inflammation and Infections of the nervous system: Neuropathology
immunoprivileged site
no lymphatics
low MHC expression
no circulating lymphocytes
innate immune system
pattern recognition receptors
astrocytes
microglia
terminology
pleocytosis
increased cell # in CSF
perivascular cuffs (PVIs)
accumulation of cells in perivascular area
cellular efflux or influx
infiltrating cells
lymphs
eosins
neuts
macrophages
portals into CNS
hematogenous
most common
breakdown of BBB
distribution
widespread
random
"seeding" where vascular density is highest
leptomeninges
choroid plxus
neural parenchyma
gray-white matter jxns
commone agents
bacteria
viruses
fungi
helminths
protozoa
neural
enter peripheral nerve
axonal transport
pathogen is shielded
direct extension from surrounding structures
