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Multisystemic Diseases of LA: Scrapie and Orf - Coggle Diagram
Multisystemic Diseases of LA: Scrapie and Orf
Scrapie
cause
PrP-Sc
sheep are natural hosts
mechanism unknown
endemic worldwide :no_entry: Aus, NZ
transmission
birthing season
placental
birthing fluid
oral
from gut to CNS
can be found in a variety of non-neural tissue
genetic susceptibility component
PrP gene
can therefore be eradicated with testing
codons
clinical signs
early
later
diagnosis
biopsy
tonsils
3rd eyelid
retropharyng LN
histopath
brain, SC
rapid collection needed
no treatment :frowning_face:
transmissable spongiform encephalopathy, The Original ®
orf
aka
contagious ecthyma
soremouth
contagious pustular dermatitis
parapox of small ruminants and camelids
transmission
enters through skin abrasion
rouhg feed
scabs falling into environment
pathogenesis
primary viremia
LNs
bone marrow
liver
secondary viremia
less common
travel to...
head
extremeties
udder
genitals
lungs
liver
incubation 3-8d
asymptomatic possible
up to 100% morbidity in young kids
treatment
no effective topicals
vaseline on lips
time
debridement of painful lesions in kids
prevention
vaccination
autogenous vaccines
ground-up scabs in saline
+/- antibiotics
unattenuated
live virus vaccine
administration
locations
inner ear
axilla
underside of tail
:no_entry:inner thigh in lactating dams
scab at site in 1-3d signifies it worked
zoonotic