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Blood + vessels development, (transitory), (definitive hematopoiesis),…
Blood + vessels development
vasculogenesis
(arise from blood islands)
hemangioblast at mesoderm (precursor cells)
Blood islands (at mesoderm near yolk sac) (week3)
vascular epithelial growth factor (VEGF) from mesoderm stimulate blood cell/vessel growth
peripheral
angioblast cells (precursors of blood vessels)
endothelial cells
primitive blood vessels
formation of primary vessels :ex:arota, cardinal veins
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center
aorta-gonad-mesonephrosregion (AGM) mesoderm cells
hematopoietic stem cells
to embryonic liver
Liver:primary hematopoietic organ (2 month to 7 month)
stem cell movement to bone marrow
Red bone marrow:definite hematopoietic organ
(transitory)
(definitive hematopoiesis)
FGF2 induction
VEGF induction
VEGF induction
form the first batch
(Primitive hematopoiesis)
PDGF+TGF-beta involves vessels maturation+modeling