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FeLV/FIV - Coggle Diagram
FeLV/FIV
FeLV
asymptomatic phase
progressive infection
30-50%
persistent viremia
disease and death
FeLV-related dz within 5y
neoplasia
ymphoma
leukemia
fibrosarcoma
pure RBC aplasia
immune mediated disease
IMHA
ITP
GN
IMPA
uveitis
peripheral lymphadenopathy
neuological dz
reproductive failure
GI dz
uncommon
test results
p27 Ag ELISA reamins positive
IFA +
intracellular
regressive infection
transient viremia
reactivation possible
may never have disease
possible FeLV-Ag neg lymphoma and myelosuppressive disorders
test results
p27 Ag + in the viremic period
negative by 16w
negative result could indicate no infection or regressive
abortive infection
no viremia
not detected on Ag tests
clear infection prior to viremia
never become Ag +
transmission
bodily fluids
saliva
nasal secretions
milk
must be actively viremic
when to test
sick
bite woulds
oral disease
known exposure
multicat environment
entire shelters
newly acquired
prior to FeLV vaccination
testing
soluable core Ab p27
ELISA
whole blood preferred
confirmatory
IFA
second ELISA several weeks later
combo test
false positives expected
proviral DNA PCR
after initial viremia
inserted into host genome
does not indicate viral replication
outcomes
management
keep inside
vaccinated w/ cores
2x vet visits + lab work
test and vaccinate housemates
treatment
secondary infections
treat lymphoma with chemotherapy
treat anemia w/ erythropoietin analogs
prevention
test new cats
vaccinate kittens and at 1y
isolate
keep inside
FIV
asymptomatic phase
reamin asymptomatic
progressive dysfunction of the immune system
transmission
bites
no latency periods
risks
free-roaming
male
who to test
sick
bitten
oral disease
known exposure
multicat homes
shelter/rescue
new acquisition
prior to FIV vaccination
kee in mind kittens may have maternal Abs
retest after 6mos
course
may have normal life expectancy
at least 4-6y
when illness presents, <1y
immunodeficiency
opportunistic infection
chronic gingivostomatitis
chronic rhinitis
immune mediated dz (GN)
peripheral lymphadenopathy
weight loss
cancer
lmpoma
SCC
neupathies
seizures
behavior changes
management
keep indoors
neuter/spay
vaccinate early in course of dz
2x annual vet visits + lab work
test housemates
treatment
treat secondary infections
chemo for lymphoma
erthyropoietin for severe non-reg anemia
antivirals maybe
AZT
human alpha interferon