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Intro to CNS Infections - Coggle Diagram
Intro to CNS Infections
structure and fxn of CNS
non-elastic
vital organ
non-regenerative
damage is almost always permanent
immune priviledge
isolated by BBB
small slow lymphatic system
lack MHC
poor antigen-presenting cells (APCs)
suppressive immune milieu
host factors of CNS infection
host species
age
tropism of agent
virulence of agent
immune status of host
all CNS infections start outside the CNS
common routes
hematogenous
bacterial
distal septic foci
vascular damage
examples
Streptococcus suis
Staphylocooccus sp
Hemophilis parasuis
Rickettsia ricketsia
extension
proximity of access
generalized disease
pyogenic foci
sequela
pleocytosis in CSF
neutrophils usually
leptomeningitis
examples
Staphylococcus sp
Arcanobacterium sp
nerves
neuroanatomical location based on route of entry
incubation period
clinical signs
examples
Rabies
Vomitng and Wasting disease
Listeria monocytogenes
"Circling disease"
Aujesky's disase
determines anatomic location of infection in the brain
viral infections
extension of systemic infections
routes to brain
hematogenous
blood to subarachnoid space
blood to brain parenchyma
blood to CSF/ventricular space
viremia prior to disease
non-supprurative lesions
examples
african swine fever
canine distemper
canine herpesvirus
classic swine fever
equine herpes virus infection
encephalitis diseases
eastern equine enceph (EEE)
western equine enceph (WEE)
Venezuelan equine enceph (VEE)
Louping Ill
tick-borne enceph
west nile
borna disease
teschen and talfan
lentiviruses
Visna
CAE-demyelination
congenital infection
border disease/BVDV
feline panleukopenia virus
pathogenesis
direct
immune mediated
toxin production
often non-specific clinical signs
other disease causes
toxins
algae
bacterial
fungal
prion disease
