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MLS - Coggle Diagram
MLS
lincoasmides
gram + bacteria
Staph
Strep
:red_cross: gram - rods
low affinity for 50S site in bacteria
examples
clindomycin
alternative to penicillin
:forbidden:horses
severe dysbiosis
gut superinfection development
swine :check:
ADME
pleuromutilins
tiamulin
large Vd
:check:swine
:check: birds
:forbidden: ruminants
good bioavailability po
can be given mos rotues
fat soluable
basic
Vd large
missed a bunch
resistance
constituituve
inducible cross resistance
if resistant to lincoamide, it will be resistant to macrolides as well
horizontal transfer
modification of 50S ribosome site
acquired methylaiton expresionn
enhanced drug efflux
enzymatic deactivation
PK/PD
azithromycin
long t1/2
good tissue penetration
long PAE
dosed at AUC0-24/MIC
time dependent bacteriostatics
short PAEs
can bebactericidal if [high] and weak species
adverse effects
gut dysbiosis
superinfections
species
rabbit
pock pets
horses
ruminants
GI disturbances
signs
diarrhea
anorexia
emesis
species
swine
cats
dogs
cardiotoxicosis
humans
don't stick yourself with his stuff
macrolides
characteristics
gram + aerobes
gram - aerobes
examples
caused increased gut motility
tylosin
:forbidden: horses
chronic colitis
mycoplasma
erythromycin
food animals
mastitis
resp infections
azithromycin
tilmycosin
resp infection in food animals
