Please enable JavaScript.
Coggle requires JavaScript to display documents.
Fluoroquinolones - Coggle Diagram
Fluoroquinolones
gram negative aerobes hate this trick!!
also gram +?
chylamidia
rickettsia
bovine respiratory disease
pylonephritis
adverse effects
GI
dysbiosis
arthropathies in young animals
chondrotoxic effects'
cat specific
retinal degeration
associated with enrofloxacin + UV
pradofloxacin is safe
can lead to blindness
PKs
ADMEs
acidic group
basic amine moiety
oral bioavailability
but not for ruminants
Large Vd
however requires higher doses to attain Cmax
good access to restricted sites
shut down baterial porins
Metabolism
some phase 1 and phase 2
secreted in urine and bile
long t1/2
examples
Orbifloxacin
resistance