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GI Pathology: Intestines - Coggle Diagram
GI Pathology: Intestines
structure
epithelium
mesenchymal cells
lymphocytes
neutrophils
eosinophils
globular leukocytes
mucous cells
enterochromaffin cells
M cells
defense
non-immunological
secretions
mucus
mucin
indigenous microbia
compete for attachment
inhibitory substances
gastric barrier
intestinal motility
epithelial turnover
immunological
IgA
cellular
diarrhea
mechanisms
increased permeability of mucosal epithelium
passive through pores of intercellular jxns
necrosis
degeneration
chronic enteritis
hypersecretion
mucosa structurally intact
absorption shouldld exceed secretion in normal animals
enterotxins
exudation
increased capillary or epithelial permeability
protein-losing enteropathy
impaired ability to absorb
malabsorption
diminished...
digestion of nutrients into smaller molecules
absorptive capacity of intestine
transport of products once absorbed
causes
reduced mucosal surface area
viral enteritis
rotavirus
necrosis of apical epithelium
dehydration
yellow diarrhea
coronavirus
necrosis of apical epithelium
more aggressive, severe atrophy
similar signs as rotavirus
infiltration
macrophages
neoplasm
amyloid
loss of mucosal brush border enzymes
lactase
maltase
sucrase
lymphatic obstruction
block transport of digested nutrients
maldigestion
defective hydrolysis of nutrients
usually pancreatic issue
intestina hypermotility
non-intestinal
hyperthyroidism
hyper adrenocorticism
chronic renal failure
pancreatitis
increased frequency in any one of the following
frequency
fluid
volume
example: bovine viral diarrhea
Flaviviridae pestivirus
transmission
vertical transmission
direct contact
forms
acute
mucosal disease
linear ulcers throughout GI tract
chronic
less severe ulcers
fetal
persistent
lways shed virus
no immune response
PI females produces PI calves
ELISA or IHC on ear skin
-itis
enteritis
colitis
typhlitis
targets
apical epi
crypt epi
microvilli
intercellular jxns
lamina propria
infiltreate
GALT
blood
lymph
morphologic classification
hemorrhagic
fibronecrotic
ulcerative
suppurative/pylogranulomatous
proliferative/hyperplastic
granulomatous