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Feline Coronavirus - Coggle Diagram
Feline Coronavirus
signs
bloated abdomen
blindness
neurologic signs
diarrhea
vomiting
wet form specific
high protein fluid accumulation in body cavities
sometimes pleural fluid (25%)
dry form specific
pyogranulomatous lesions
usually appear in
LNs
CNS
eyes
can appear in any organ
cause specific organ dysfunction
ocular
anterior uveitis
blindness
hyphema
hypopyon
chorioretinitis
retinal detachment
hemorrhage
seizures
ataxia
liver failure
kidney failure
diagnosis
CBC
anemia
lymphopenia
serum
serum chemistry
hypoalbuminemia
hyperbilirubinemia
hyperglobulinemia
serology
immunofluorescent Ab
ELISA
test for FeCoV Ab
protein electrophoresis
polyclonal gammopathy/ high gamma globulin levels
IHC
antigen within tissue macrophages
usually post-mortem
immunofluorescence/immunocytochem
high + predictive value
poor negative predictive
detection of FeCoV macrophages in effusion
CSF
marked pleocytosis (lots of cells)
highprotein
FeCoV Ab
can be normal
RT-PCR
can be specific to FIP
use cell-free abdominal or thoracic effusion
transmission
oronasal
fecal-oral
fomites
3mo-3y most common age group
multicat locations
sporadic presentation
treatment
self-limitng diarrhea
supportive care
probiotics
fluids
FIP
prednisone 2-4mg/kg once daily
suppression of immune response
used to be palliative and euthanasia
"black market"
GS441
GC376
targets 3C-like proteases
prognosis
poor
median survival 9-38d
negative predictors
hyperbilirubinemia
lymphopenia
high volume effusion
etiology
type 1
predominant
type 2
recombo of canine and feline coronaviruses
causes
GI disease
feline infectious peritonitis (FIP)
FIP pathogenesis
macrophage trophism
essential step in FIP progression
systemic pyogranulomatous vasculitis
perivascular
exudation of plasma proteins
"wet form"
RBC damage from vascuitis
yellow color fluid from RBC breakdown
clotting and complement factor activation
DIC
belly full of fluid
produce Abs, but inadequate cell-immune mediated response
granuloma/pyogranuloma formation
"dry form"
can occur anywhere in the body
Abs produced with partially protective cell-mediated immunity
type II & III hypersensitivity
FIP less likely in cats that produces Abs with aggressive cell-mediated immunity
latent virus
may reactivate
necropsy
gross
histopath
missing
prevention
breeding precautions
isolated queening in disinfected room
test queen
test 10w old kittens
